1. Application of Transgenic and Gene-Targeted Mice to Dissect Mechanisms of Lung Disease -- Emphysema -- 2. Models of Genetic Emphysema: The C57B1/6J Mice and their Mutants: Tight-Skin, Pallid and Beige Giuseppe Lungarella, Eleonora Cavarra and -- 3. ?1-Antitrypsin Deficiency -- 4. Recombinant SLPI: Emphysema and Asthma -- 5. Elastase Inhibitors in the Lung: Expression and Functional Relationships -- 6. Regulation of Neutrophil Proteinases -- 7. Control of Connective Tissue Genes -- Infection -- 8. Genetic Models of Bacterial Lung Infection -- 9. Genetics of Bacteria: Role in Pathogenesis of Infection of the Respiratory Tract -- 10. Polymerase Chain Reaction in the Diagnosis of Respiratory Tract Infections -- 11. Cystic Fibrosis -- 12. Respiratory Bacterial Infections in Patients with Cystic Fibrosis: Pathogenicity and Implications for Serine Proteinase Inhibitor Therapy