Title | Cytokines in Severe Sepsis and Septic Shock [electronic resource] / edited by Heinz Redl, Gรผnther Schlag |
---|---|
Imprint | Basel : Birkhรคuser Basel : Imprint: Birkhรคuser, 1999 |
Connect to | http://dx.doi.org/10.1007/978-3-0348-8755-7 |
Descript | XX, 372 p. online resource |
Induction -- Inducers -- Endotoxin as an inducer of cytokines -- Acute lung inflammation in septic shock of the cytokine release induced by bacterial superantigens -- Lipopolysaccharide signaling pathways and their role in the development of the systemic inflammatory response syndrome -- Predisposing factors -- Predisposing factors: Effect of sex, nutritional factors and age on immunity following shock and sepsis -- Genetics: Cytokine polymorphisms -- Diagnostic -- Possibilities and problems of cytokine measurements -- Soluble TNF receptors -- Relevance of surrogate tests in intensive care patiens or โHeisenberg at the ICUโ -- Actions (selected events) -- Nitric oxide and endothelin-1 in circulatory shock involving cytokines -- Multistep processes in neutrophil homotypic aggregation and tissue injury -- Cytokines, coagulation and fibrinolysis -- Apoptosis: Its role in the systemic inflammatory response syndrome and the involvement of cytokines -- Importance of cytokine metabolism for malnutrition, catabolism and endocrinological state in sepsis -- Therapy -- Endotoxin scavengers as a therapeutic strategy for sepsis -- Interfering with the production of cytokines in sepsis -- Neutralizing antibodies and receptor constructs -- Immunomodulation following shock and sepsis -- Gene therapy โ an alternative approach for anti-cytokine therapies -- The failure of clinical trials in sepsis -- The failure of clinical trials in sepsis: Challenges of pre-clinical models -- The failure of clinical trials in sepsis: Challenges of clinical trial design