Title | Pharmacological Sciences: Perspectives for Research and Therapy in the Late 1990s [electronic resource] / edited by A. Claudio Cuello, Brian Collier |
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Imprint | Basel : Birkhรคuser Basel, 1995 |
Connect to | http://dx.doi.org/10.1007/978-3-0348-7218-8 |
Descript | XXII, 520 p. online resource |
Drug Receptors -- Molecular Studies of Glutamate Receptors -- GABA Receptor Pharmacology -- Serotonin Receptor Subtypes: Exploiting their Therapeutic Potential -- Peptide Receptor Antagonists -- Angiotensin Receptor Subtypes and their Pharmacology -- Foundations and Future of Molecular Pharmacology -- Signal Transduction -- Lipid Messengers and Protein Kinase C for Intracellular Signalling -- Mechanisms for the Regulation of Inositol Lipid Signaling and Calcium Homeostasis -- G-Protein-Linked Receptors and Tyrosine Kinase-Mediated Signal Transduction Pathways: A Mid-1990s Perspective, with Working Hypotheses -- Receptor-G Protein Effector Coupling: Coding and Regulation of the Signal Transduction Process -- Pharmacology of Ion Channels -- Novel Aspects of the Pharmacology of Calcium Channel Modulators -- Calcium Channels, Calcium Channel Antagonists and the Functioning of the Gastrointestinal Tract -- Aspects of Potassium Channel Modulation -- Drug Metabolism -- The Proliferating P450s: Providers of Polysubstrate Pharmacology -- Human Cytochromes P450: Regulation and Functional Variability -- Drug Conjugation: Diversity and Biological Significance -- Interethnic Differences in Drug Metabolism and Pharmacogenetics -- Dietary Effects on Drug Metabolism -- Neuropharmacology -- Neurotransmitter Functions of Mammalian Tachykinins: Substance P and Neurokinin A -- Molecular Events Underlying the Anti-Opioid Effect of Cholecys-tokinin Octapeptide (CCK-8) in the Central Nervous System -- Pharmacology of Excitatory Amino Acid Receptors -- GABA Receptors: Recent Advances -- Therapeutic Possibilities with Serotonergic Drugs -- The Pharmacology of Neurotrophic Factors -- New Perspectives in the Pharmacology of Parenchimal Brain Anoxia-Ischemia -- Pathophysiology and Future Pharmacotherapy of Chronic Pain -- Neurohormonal Systems Underlying Drug Addiction: Relevance for Treatment Strategies -- Molecular and Cellular Mechanisms in Neurosecretion -- Purines -- Role of Purines in the Central Nervous System -- Adenosine: Some Therapeutic Applications and Prospects -- Cardiovascular Pharmacology -- Endothelins: Recent Progress -- Drugs Directly Affecting the Arterial Wall -- Chronic Drug Treatment of Essential Hypertension -- Role of Potassium Channel Blockers in the Treatment of Cardiac Arrhythmias -- Nitric Oxide -- Nitric Oxide in the Cardiovascular System -- Role of the L-Arginine-NO-Cyclic GMP Pathway in NANC Neurotransmission -- Endocrine Pharmacology and Immunopharmacology -- Neuroendocrine Hormones and the Immune System -- Selected Aspects of the Immunopharmacology of Cytokines -- Targeted Therapy of Cancer and Autoimmune Diseases -- The Pharmacology of Gene Expression -- Antisense Therapeutics -- Pulmonary Pharmacology -- Molecular Mechanisms of Anti-Asthma Therapy -- Chemotherapy -- Membrane Transport of Anticancer Drugs and Drug Resistance -- Toxicology -- Importance of Individual Enzymes in the Control of Ultimate Carcinogens -- Molecular and Cellular Aspects of Chemical Carcinogenesis -- Alterations in Cell Signaling and Cytotoxicity -- Calcium-Dependent Mechanisms in Drug Toxicity and Cell Killing -- Liver Toxicity Mediated by Leukocytes and Kupffer Cells -- Regulatory Requirements for Drug Registration -- Harmonization of Drug Regulation and Trial Requirements: Clinical Pharmacological Aspects and Responsibilities -- Pharmacological Methods -- In Vivo Magnetic Resonance in Pharmacological Research -- Application of Cell Culture Systems to the Study of Drug Transport and Metabolism -- Instructional Methods -- Providing Quality Education in Pharmacology: The Affordable Options