The main themes presented in this volume are exercise intolerance and muscle contracture. These two topics could seem different at first sight but share common clinical features. For instance, symptoms of exercise intolerance are myalgias and cramps but metabolic contractures as well. Likewise exercise intolerance is sometimes due to dystrophinopathy, itยญ self causing contractures. Therefore, it is justified to gather these two synยญ dromes in one study. Exercise intolerance and muscle contracture could seem wellยญ known, even obsolete. It is not right. A reappraisal of these has beยญ come necessary for two reasons. First of all there are many new causes of exercise intolerance; secondly, the pathophysiology remains obยญ scure in particular for muscle contracture and a clear classification is probably possible. There is no book devoted to exercise intolerance and muscle contracยญ ture. This volume is divided in two parts related to the above topics. The two sections are introduced by a didactic and general overview, describยญ ing the main symptoms, classification and classical etiology. The other chapters, written by the best experts, present the recent advances in these syndromes and show many new aspects: new glycogenosis or mitochondriopathies, dystrophinopathies, malignant hyperthermia, myยญ otonic disorders. Pathophysiology and classification of persistent conยญ tractures are described as well as therapy. Each chapter is thoroughly referenced, representing important progress in research in the field
