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TitleEpilepsy and the Ketogenic Diet [electronic resource] / edited by Carl E. Stafstrom, Jong M. Rho
ImprintTotowa, NJ : Humana Press : Imprint: Humana Press, 2004
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Descript XX, 355 p. 41 illus. online resource


Recent advances in our understanding of the ketogenic diet (KD)-a high-fat, low-carbohydrate, adequate-protein diet used for the treatment of medically intractable epilepsy-have produced a resurgence of interest in, and application of, this valuable treatment for the epileptic patient. In Epilepsy and the Ketogenic Diet, internationally recognized researchers and clinicians from around the world synthesize the current state of the science and clinical practice of the KD. On the basic science side, the authors review what is known about the basic biochemical mechanisms of action of the KD at the molecular level, spelling out in detail its complex interactions with nutrient components, neurodevelopment, brain biochemistry, and physiology. They also examine the effects of the KD on the metabolism of fats, amino acids, and carbohydrates in the central nervous system at both the macro and cellular levels. On the clinical side, physicians, dietitians, and nurses provide a full range of information concerning the treatment of seizures with KD, including a detailed assessment of the indications for, and the contraindications and/or complications that arise from its use, detailed equations that permit the caregiver to calculate the actual amounts of different types of foods that can be included in daily diet plans, and documented information on the carbohydrate and calorie content of hundreds of commonly used drugs. Numerous relevant tables, graphs, and figures, as well as up-to-date references, consistent use of terms across chapters, and a highly annotated index ensure easy access to needed information. Illuminating and highly practical, Epilepsy and the Ketogenic Diet constitutes a unique benchmark synthesis of up-to-date clinical and scientific information that explains the mechanisms behind the KD and how its maximum therapeutic benefits may be realized in the epileptic patient with minimal adverse effects


I. Background -- 1 An Introduction to Seizures and Epilepsy: Cellular Mechanisms Underlying Classification and Treatment -- 2 History and Origin of the Ketogenic Diet -- II. Clinical Aspects -- 3 The Ketogenic Diet: The Physicianโ{128}{153}s Perspective -- 4 Clinical Use of the Ketogenic Diet: The Dietitianโ{128}{153}s Role -- 5 How to Maintain and Support a Ketogenic Diet Program: A Nursing Perspective -- 6 Efficacy of the Ketogenic Diet -- 7 The Ketogenic Diet in Adults -- 8 Indications and Contraindications of the Ketogenic Diet -- 9 Complications of the Ketogenic Diet -- 10 Measuring and Interpreting Ketosis and Fatty Acid Profiles in Patients on a High-Fat Ketogenic Diet -- 11 Insights From Neuroimaging Studies Into Ketosis and the Ketogenic Diet -- 12 Potential Applications of the Ketogenic Diet in Disorders Other Than Epilepsy -- 13 Dietary Treatments for Epilepsy Other Than the Ketogenic Diet -- III. Basic Science Perspectives -- 14 Effects of the Ketogenic Diet on Cerebral Energy Metabolism -- 15 The Ketogenic Diet: Interactions With Brain Amino Acid Handling -- 16 Molecular Regulation of Ketogenesis -- 17 The Effects of Ketone Bodies on Neuronal Excitability -- 18 Effects of the Ketogenic Diet on Acute Seizure Models -- 19 Caloric Restriction and Epilepsy: Historical Perspectives, Relationship to the Ketogenic Diet, and Analysis in Epileptic EL Mice -- 20 The Role of Norepinephrine in the Anticonvulsant Mechanism of Action of the Ketogenic Diet -- 21 Galanin and Neuropeptide Y: Orexigenic Neuropeptides Link Food Intake, Energy Homeostasis, and Seizure Susceptibility -- 22 The Neuroprotective and Antiepileptogenic Effects of the Ketogenic Diet -- Afterword: A Parentโ{128}{153}s Perspective on Childhood Epilepsy: The Things I Wish They Had Told Us -- Epilogue -- Appendix A: The Carbohydrate and Caloric Content of Drugs -- Appendix B: Ketogenic Diet Resources

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