Title | Nucleic Acid Therapeutics in Cancer [electronic resource] / edited by Alan M. Gewirtz |
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Imprint | Totowa, NJ : Humana Press : Imprint: Humana Press, 2004 |
Connect to | http://dx.doi.org/10.1007/978-1-59259-777-2 |
Descript | X, 221 p. online resource |
I. Introduction and Perspective -- 1 Antisense Methodology: An Assessment After 25 Years -- 2 Nucleic Acid Therapeutics: An Introduction -- II. Basic Methodology -- 3 Targeted Genome Modification Via Triple Helix Formation -- 4 Therapeutic Applications of Ribozymes -- 5 Use of Catalytic DNA in Target Validation and Therapeutics -- 6 Targeted Destruction of Small, Stable RNAs: Principles Applicable to Antisense Therapies -- 7 Mechanism of Action of Antisense RNA in Eukaryotic Cells -- III. Delivery -- 8 The Transport of Oligonucleotides Into Cells -- 9 Peptide-Mediated Delivery of Antisense Oligonucleotides and Related Material -- 10 Molecular Vectors for Gene Delivery to Cancer Cells -- IV. Targeting -- 11 Considerations on the Design of Antisense Oligonucleotides -- 12 Identification of Hybridization Accessible Sequence in Messenger RNA -- V. Clinical Targets -- 13 Nucleic Acids As Gene Targeting Therapeutics -- 14 LY900003 (Isis 3521) and G3139 (Genasense; Oblimersen): Phosphorothioate Antisense Oligonucleotides With Pleiotropic Mechanisms of Action -- 15 Antisense Protein Kinase A-RI? Restores Normal Signal Transduction Signatures to Inhibit Tumor Growth