Title | Handbook of Anticancer Pharmacokinetics and Pharmacodynamics [electronic resource] / edited by William D. Figg, Howard L. McLeod |
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Imprint | Totowa, NJ : Humana Press : Imprint: Humana Press, 2004 |
Connect to | http://dx.doi.org/10.1007/978-1-59259-734-5 |
Descript | XV, 623 p. online resource |
1 Molecular Targets -- 2 Preclinical Screening for New Anticancer Agents -- 3 Mouse Models in Cancer Drug Discovery and Development -- 4 Defining the Starting Dose: Should It Be Based on mg/kg, mg/m2or Fixed? -- 5 Phase I Trials in Oncology: Design and Endpoints -- 6 Analytical Methods: Development, Validation, and Clinical Applicability -- 7 Validation and Control of Bioanalytical Methods in Clinical Drug Development -- 8 Clinical Pharmacology Overview -- 9 Pharmacokinetic Modeling -- 10 Pharmacodynamic Modeling -- 11 Pharmacometric Knowledge-Based Oncology Drug Development -- 12 Protein Binding of Anticancer Drugs -- 13 Metabolism (Non-CYP Enzymes) -- 14 Cytochrome P450 and Anticancer Drugs -- 15 Polymorphisms in Genes of Drug Targets and Metabolism and in DNA Repair -- 16 Drug Interactions -- 17 ABC Transporters: Involvement in Multidrug Resistance and Drug Disposition -- 18 Intrathecal Chemotherapy -- 19 Use of Microdialysis in Preclinical and Clinical Development of Anticancer Agents -- 20 Regional Therapy of Cancer Using Continuous Hyperthermic Peritoneal Perfusion or Vascular Isolation and Perfusion Techniques -- 21 Isolated Lung Perfusion for the Treatment of Inoperable Pulmonary Malignancies -- 22 Pharmacokinetics of Isolated Lung Perfusion with Antitumor Agents -- 23 Central Nervous System Malignancy and Clinical Pharmacology -- 24 Pharmacokinetics of Anticancer Drugs in Children -- 25 Clinical Pharmacokinetics in the Elderly -- 26 The Combination of Angiogenesis Inhibitors and Radiotherapy for the Treatment of Primary Tumors -- 27 Gene Therapy for the Treatment of Cancer -- 28 Vaccines for the Treatment of Cancer -- 29 Pharmacokinetics of Antibodies and Immunotoxins in Mice and Humans -- 30 Pharmacokinetics of Biologicals -- 31 ExposureโResponse Relationship of Anticancer Agents: A Clinical Pharmacology and Biopharmaceutics Regulatory Perspective -- 32 Identifying Agents to Test in Phase III Trials -- 33 Clinical Trial Designs for Approval of New Anticancer Agents: A Clinical Science -- 34 Pharmacogenetic Counseling