Title | The IGF System [electronic resource] : Molecular Biology, Physiology, and Clinical Applications / edited by Ron G. Rosenfeld, Charles T. Roberts |
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Imprint | Totowa, NJ : Humana Press : Imprint: Humana Press, 1999 |
Connect to | http://dx.doi.org/10.1007/978-1-59259-712-3 |
Descript | XII, 788 p. online resource |
1 Historical Perspective: The Origins and Development of the Somatomedin Hypothesis -- I Molecular Biology of the IGF System -- 2 Molecular Biology of IGF-I and IGF-II -- 3 Regulation of IGF Gene Expression -- 4 Molecular Biology of the Type 1 IGF Receptor -- 5 Molecular Biology of the IGF-II/Mannose-6-Phosphate Receptor -- 6 Molecular Biology of the IGF Binding Proteins -- II Biological Actions of the IGFs -- 7 IGF-I Receptor Function: Transducing the IGF-I Signal into Intracellular Events -- 8 Type 2 IGF Receptor-Mediated Events -- 9 Alternative IGF-Related Receptors -- 10 IGF Binding Proteins as Modulators of IGF Action -- 11 IGF-Independent Actions of the IGF Binding Proteins -- 12 IGF Binding Proteins and Extracellular Matrix -- 13 Biological Actions of Proteolytic Fragments of the IGF Binding Proteins -- 14 The IGF Binding Protein Superfamily -- 15 IGFs and Cell Growth -- 16 Posttranslational Modification of the IGF Binding Proteins -- III IGF Physiology -- 17 IGFs in the Female Reproductive System -- 18 The IGF Axis in the Male Reproductive System -- 19 IGFs and the Nervous System -- 20 IGF System Components and Their Role in Bone Metabolism -- 21 IGFs and Skeletal Muscle -- 22 IGFs and the Digestive Tract -- 23 Actions of IGF System Proteins from Studies of Transgenic and Gene Knockout Models -- IV Clinical Aspects of the IGFs -- 24 Metabolic Effects of IGFs -- 25 Clinical Uses of IGF-I and IGF Binding Protein Assays -- 26 IGF Binding Protein Proteolysis in Various Clinical States -- 27 IGF Deficiency -- 28 Tumor Hypoglycemia Linked to IGF-II -- 29 IGFs in the Evaluation of Acromegaly -- 30 IGF in the Treatment of Diabetes -- 31 IGF-I Treatment of Growth Hormone Insensitivity