Title | Molecular Neuropharmacology [electronic resource] : Strategies and Methods / edited by Arne Schousboe, Hans Brรคuner-Osborne |
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Imprint | Totowa, NJ : Humana Press : Imprint: Humana Press, 2004 |
Connect to | http://dx.doi.org/10.1007/978-1-59259-672-0 |
Descript | XI, 271 p. online resource |
I. Molecular Pharmacology of Glutamate Receptors -- 1 Computational Studies of Ligand-Receptor Interactions in Ionotropic Glutamate Receptors -- 2 Delineation of the Physiological Role of Kainate Receptors by Use of Subtype Selective Ligands -- 3 Molecular Pharmacology of the Metabotropic Glutamate Receptors -- II. Molecular Pharmacology of GABA Receptors -- 4 Functional Characterization of GABAA Receptor Ligands In Vitro: Correlation With In Vivo Activity -- 5 In Vivo Function of GABAA Receptor Subtypes Unraveled With Mutant Mice -- 6 Characterization of the GABAA Receptor Recognition Site Through Ligand Design and Pharmacophore Modeling -- 7 The GABAB Receptor: From Cloning to Knockout Mice -- III. Molecular Pharmacology of Transmitter Transporters -- 8 Structure and Molecular Characterization of the Substrate-Binding Sites of the Dual-Function Glutamate Transporters -- 9 Allosteric Modulation of Glutamate Transporters -- 10 Characterization of the Substrate-Binding Site in GABA Transporters -- 11 Insights From Endogenous and Engineered Zn2+ Binding Sites in Monoamine Transporters -- 12 A Structural Context for Studying Neurotransmitter Transporter Function -- 13 Functional Mechanisms of G Protein-Coupled Receptors in a Structural Context