Principles of Molecular Oncology [electronic resource] / edited by Miguel H. Bronchud, MaryAnn Foote, Giuseppe Giaccone, Olufunmilayo I. Olopade, Paul Workman
Imprint
Totowa, NJ : Humana Press : Imprint: Humana Press, 2004
Drawing on four years of significant scientific advances and clinical developments, the editors of Principles of Molecular Oncology, Second Edition, have thoroughly updated the highly praised first edition and added new chapters to reflect the knowledge emerging from research on genomics, proteomics, chemoprevention strategies, new molecular targets, therapeutic monoclonal antibodies, and innovative cytotoxic and cytostatic small-molecular-weight compounds. The first edition of this book (Humana Press, 2000) was also the first comprehensive presentation of the concept of cancer as a "disease process" involving key regulatory pathways. The second edition reaffirms this dynamic concept, incorporating more recent evidence, and introducing such new topics of special interest as the combination of molecular diagnostics-expression profiling of genes and proteins-with developmental therapeutics, and the "binary state" concept (active/inactive) that seeks more relevant targets within the global molecular matrix of a given cancer. Comprehensive and intellectually stimulating, Principles of Molecular Oncology, Second Edition not only clearly elucidates the fundamentals of this dramatically advancing field, but also interprets the vast and often complex molecular data available. It fills a much-neglected gap between "information" and "knowledge," and holds out the hope of new anticancer strategies that will reduce cancer cell proliferation and significantly reduce metastasis
CONTENT
1 Selecting the Right Targets for Cancer Therapy -- 2 Clinical Importance of Prognostic Factors: Moving from Scientifically Interesting to Clinically Useful -- 3 Genetic Markers in Sporadic Tumors -- 4 Genetic Markers in Breast Tumors with Hereditary Predisposition -- 5 Cellular and Tissue Markers in Solid Tumors -- 6 Molecular and Pathologic Characterization of Human Tumors -- 7 Circulating Tumor Markers -- 8 Proteomics-Based Approaches: New Opportunities in Cancer Research -- 9 Growth Factor Signaling Pathways in Cancer -- 10 Estrogen Action and Breast Cancer -- 11 Cyclin-Dependent Kinases and Their Regulators as Potential Targets for Anticancer Therapeutics -- 12 Angiogenesis Switch Pathways -- 13 Invasion and Metastasis -- 14 Molecular Pathways of Drug Resistance -- 15 Genomic Instability, DNA Repair Pathways, and Cancer -- 16 Immunotherapy for Human Cancer: Evidence and Obstacles -- 17 Treatment with Monoclonal Antibodies -- 18 Emerging Molecular Therapies: Drugs Interfering with Signal Transduction Pathways -- 19 Treatment of Carcinogenesis -- 20 Suicide Gene Therapy
