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TitleDNA Damage and Repair [electronic resource] : Volume 2: DNA Repair in Higher Eukaryotes / edited by Jac A. Nickoloff, Merl F. Hoekstra
ImprintTotowa, NJ : Humana Press : Imprint: Humana Press, 1998
Connect tohttp://dx.doi.org/10.1007/978-1-59259-455-9
Descript XIII, 639 p. 50 illus. online resource

SUMMARY

DNA Damage and Repair offers a critical, cutting-edge review of all major aspects of DNA repair in a wide variety of organisms, including every important model system. Volume II: DNA Repair in Higher Eukaryotes focuses mammalian systems and human genetic disease and cancer, emphasizing the significant progress that has been made in the past five years. Written by award-winning researchers at the forefront of their fields, each chapter has undergone a rigorous peer-review cycle to ensure definitive and comprehensive treatment of its topic. Extensive up-to-date references, along with clear figures illustrating complex relationships between DNA repair and other DNA dynamic processes and cell functions, bring this volume to the active frontiers of research. Major topics include UV and X-ray repair, repair of chemical damage, recombinational repair, mismatch repair, transcription-repair coupling, and the role of DNA repair in disease prevention. A complementary volume, Volume I: DNA Repair in Prokaryotes and Lower Eukaryotes , focuses on DNA damage and repair in prokaryotic and model eukaryotic systems. This major new treatise provides the reader with up-to-date critical surveys of every important area of research on DNA damage and the repair mechanisms in each major system currently under investigation. Authoritative and timely, DNA Damage and Repair is certain to become the new standard reference and resource in the field


CONTENT

1 Overview -- 2 DNA Photolyases -- 3 Cellular Responses to Methylation Damage -- 4 Exogenous Carcinogen-DNA Adducts and Their Repair in Mammalian Cells -- 5 Nature of Lesions Formed by Ionizing Radiation -- 6 Mammalian Enzymes for Preventing Mutations Caused by Oxidation of Guanine Nucleotides -- 7 Biochemistry of Mammalian DNA Mismatch Repair -- 8 Short Patch Mismatch Repair in Mammalian Cells -- 9 Role of HMG and Other Proteins in Recognition of Cisplatin DNA Damage -- 10 TFIIH: A Transcription Factor Involved in DNA Repair and Cell-Cycle Regulation -- 11 DNA Polymerase Involvement in DNA Repair -- 12 Cellular Functions of Mammalian DNA Ligases -- 13 Modulations in Chromatin Structure During DNA Damage Formation and DNA Repair -- 14 Transcriptional Responses to Damage Created by Ionizing Radiation: Molecular Sensors -- 15 Posttranslational Mechanisms Leading to Mammalian Gene Activation in Response to Genotoxic Stress -- 16 Mechanisms for DNA Double-Strand Break Repair in Eukaryotes -- 17 Mutant Rodent Cells Defective in DNA Double-Strand Break Repair -- 18 Nucleotide Excision Repair: Its Relation to Human Disease -- 19 Cellular Responses to DNA Damage and the Human Chromosome Instability Syndromes -- 20 Genetics of Mismatch Repair, Microsatellite Instability, and Cancer -- 21 Mammalian Cell-Cycle Responses to DNA-Damaging Agents -- 22 Poly(ADP-Ribose) Polymerase in Response to DNA Damage -- 23 DNA Topoisomerases in DNA Repair and DNA Damage Tolerance -- 24 Molecular Approaches for Detecting DNA Damage -- 25 Radiation-Induced Damage and the Formation of Chromosomal Aberrations -- 26 Whole Organism Responses to DNA Damage: Modulation by Cytokines of Damage Induced by Ionizing Radiation -- 27 DNA Damage and Repair in the Clinic


Life sciences Biochemistry Enzymology Cell biology Life Sciences Biochemistry general Cell Biology Enzymology



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