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TitleCytokine Knockouts [electronic resource] / edited by Giamila Fantuzzi
ImprintTotowa, NJ : Humana Press : Imprint: Humana Press, 2003
Edition Second Edition
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Descript XIX, 471 p. online resource


Carrying on the high standards of the much-praised first edition (Durum and Muegge, Cytokine Knockouts, 1998), Giamila Fantuzzi and a panel of experts have generated completely new chapters to reflect the use of many novel mouse strains and the hundreds of recent studies on cytokine physiology. Comprehensive reviews of the numerous, often surprising results obtained using cytokine knockout mice are provided, along with much important information about cytokine biology. For those not familiar with cytokine research, in part I the authors present a critical discussion of the advantages and disadvantages of using cytokine knockout mice in various fields of research. In their discussion of research methodology and data interpretation, the writers stress the need for caution when trying to interpret data, especially when these may affect clinical practice, and the danger of forgetting the possible effects of redundancy and of unspecified perturbations in the immune system when a single gene is deleted. Chapters dealing with mice deficient for single cytokines and/or cytokine receptors are presented in part II. Cutting-edge and highly instructive, Cytokine Knockouts, Second Edition illuminates for researchers today both the usefulness of cytokine knockout mice to study a wide variety of cytokine phenomena and the possible complications of such studies


I. Cytokine Knockouts in Models of Human Disease -- 1. Cytokine Knockouts in Inflammation -- 2. The Use of Cytokine Knockouts to Study Host Defense Against Infection -- 3. The Use of Cytokine Knockouts in Animal Models of Autoimmune Disease -- 4. The Use of Cytokine Knockout Mice in Cancer Research -- 5. The Use of Cytokine Knockout Mice in Neuroimmunology -- II. Cytokine Knockout Mice -- 6. The Role of IL-1 in the Immune System -- 7. IL-1 Receptor Antagonist-Deficient Mice -- 8. A Unique Role for IL-2 in Self-Tolerance -- 9. Molecular Basis for Binding Multiple Cytokines by ?c: Implications for X-SCID and Impaired ?c-Dependent Cytokine Receptor Function -- 10. G-CSF, GM-CSF, and IL-3 Knockout Mice -- 11. IL-4 Knockout Mice -- 12. Role of IL-5 in Immune and Pathological Responses in the Mouse -- 13. IL-6 Knockout Mice -- 14. IL-10 and IL-2 Knockout Mice: Effect on Intestinal Inflammation -- 15. IL-12-Deficient Mice -- 16. IL-13 and Double IL-4/IL-13 Knockout Mice -- 17. IL-15: Insights from Characterizing IL-15-Deficient Mice -- 18. IL-18 and IL-18 Receptor Knockout Mice -- 19. Mice Knockouts for Chemokines and Chemokine Receptors -- 20. IFN-? and IFN-? Receptor Knockout Mice -- 21. Macrophage Migration Inhibitory Factor (MIF)-Deficient Mice -- 22. Osteopontin, a Surprisingly Flexible Cytokine: Functions Revealed from Osteopontin Knockout Mice -- 23. RANKL, RANK, and OPG -- 24. Targeting the TGF-? Pathway In Vivo: Defining Complex Roles for TGF-? Signaling in Immune Function, Wound Healing, and Carcinogenesis -- 25. Physiologic Roles of Members of the TNF and TNF Receptor Families as Revealed by Knockout Models

Medicine Immunology Biomedicine Immunology


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