Title | Cytokine Knockouts [electronic resource] / edited by Giamila Fantuzzi |
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Imprint | Totowa, NJ : Humana Press : Imprint: Humana Press, 2003 |
Edition | Second Edition |
Connect to | http://dx.doi.org/10.1007/978-1-59259-405-4 |
Descript | XIX, 471 p. online resource |
I. Cytokine Knockouts in Models of Human Disease -- 1. Cytokine Knockouts in Inflammation -- 2. The Use of Cytokine Knockouts to Study Host Defense Against Infection -- 3. The Use of Cytokine Knockouts in Animal Models of Autoimmune Disease -- 4. The Use of Cytokine Knockout Mice in Cancer Research -- 5. The Use of Cytokine Knockout Mice in Neuroimmunology -- II. Cytokine Knockout Mice -- 6. The Role of IL-1 in the Immune System -- 7. IL-1 Receptor Antagonist-Deficient Mice -- 8. A Unique Role for IL-2 in Self-Tolerance -- 9. Molecular Basis for Binding Multiple Cytokines by ?c: Implications for X-SCID and Impaired ?c-Dependent Cytokine Receptor Function -- 10. G-CSF, GM-CSF, and IL-3 Knockout Mice -- 11. IL-4 Knockout Mice -- 12. Role of IL-5 in Immune and Pathological Responses in the Mouse -- 13. IL-6 Knockout Mice -- 14. IL-10 and IL-2 Knockout Mice: Effect on Intestinal Inflammation -- 15. IL-12-Deficient Mice -- 16. IL-13 and Double IL-4/IL-13 Knockout Mice -- 17. IL-15: Insights from Characterizing IL-15-Deficient Mice -- 18. IL-18 and IL-18 Receptor Knockout Mice -- 19. Mice Knockouts for Chemokines and Chemokine Receptors -- 20. IFN-? and IFN-? Receptor Knockout Mice -- 21. Macrophage Migration Inhibitory Factor (MIF)-Deficient Mice -- 22. Osteopontin, a Surprisingly Flexible Cytokine: Functions Revealed from Osteopontin Knockout Mice -- 23. RANKL, RANK, and OPG -- 24. Targeting the TGF-? Pathway In Vivo: Defining Complex Roles for TGF-? Signaling in Immune Function, Wound Healing, and Carcinogenesis -- 25. Physiologic Roles of Members of the TNF and TNF Receptor Families as Revealed by Knockout Models