Global gene expression profiling is a new and comprehensive approach to the investigation of tumor biology that has the potential to sharply alter the future of cancer research, diagnostic pathology, and clinical oncology. In Expression Profiling of Human Tumors: Diagnostic and Research Applications, over 20 leading investigators offer the first thorough review of the application of this novel technology to human tumors. The authors focus on the analysis of human tissue samples for a variety of cancers, including breast, colorectal, lung, renal, ovarian, bone, and brain tumors, among others. For each cancer type, the authors assess the potential of the approach in reaching more precise diagnoses, as well as in the identification of prognostic markers, therapeutic targets, and gene expression patterns that accurately predict therapeutic response. A section on the technology and its novel analytical methods explains both the theory and practice of comprehensive gene expression profiling Timely and topical, Expression Profiling of Human Tumors: Diagnostic and Research Applications provides every cancer researcher, oncologist, pathologist, and cancer surgeon an essential introduction to the most promising high-throughput investigative approach in molecular biology today-a technology that is already dramatically reshaping the future of cancer research, diagnostic pathology, and clinical oncology
CONTENT
I. Introduction -- 1 Introduction: Present and Potential Impact of Expression Profiling Studies of Human Tumors -- II. Technical Aspects -- 2 cDNA Microarrays -- 3 Oligonucleotide Microarrays -- 4 Serial Analysis of Gene Expression (SAGE) in Cancer Research -- 5 Tissue Arrays -- 6 Microarray Data Analysis: Cancer Genomics and Molecular Pattern Recognition -- 7 The Role of Tumor Banking and Related Informatics -- III. Applications -- 8 Characterization of Gene Expression Patterns for Classification of Breast Carcinomas -- 9 Microarray Analysis of Colorectal Cancer -- 10 Gene Expression Analysis of Prostate Carcinoma -- 11 Classification of Human Lung Carcinomas by mRNA Expression Profiling -- 12 Molecular Profiling of Bladder Cancer Using High-Throughput DNA Microarrays -- 13 Gene Expression Profiling of Renal Cell Carcinoma and its Clinical Implications -- 14 Expression Profiling of Pancreatic Ductal Adenocarcinoma -- 15 Gene Expression in Ovarian Carcinoma -- 16 Classification of Pediatric Tumors Using DNA Microarrays -- 17 Transcriptomes of Soft Tissue Tumors: Pathologic and Clinical Implications -- 18 Gene Expression Profiling in Lymphoid Malignancies -- 19 Gene Expression Profiling of Brain Tumors -- 20 Expression Profiling of Bone Tumors
