Title | Fluoropyrimidines in Cancer Therapy [electronic resource] / edited by Youcef M. Rustum |
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Imprint | Totowa, NJ : Humana Press : Imprint: Humana Press, 2003 |
Connect to | http://dx.doi.org/10.1007/978-1-59259-337-8 |
Descript | XII, 326 p. online resource |
1 Relative Role of 5-Fluorouracil Activation and Inactivation Pathways on its Cytotoxic Effects: Preclinical and Clinical Modulation -- 2 Dihydropyrimidine Dehydrogenase and Treatment by Fluoropyrimidines: Past and Future Directions -- 3 Biochemical Bases of the 5-FluorouracilโFolinic Acid Interaction and of its Limitations: A Retrospective Analysis -- 4 Molecular Mechanisms Regulating the Expression of Thymidylate Synthase -- 5 Regulation of Thymidylate Synthase Gene Expression and Drug Response: Posttranscriptional Regulation and Cell Population Density -- 6 Death Receptor Signaling in the Mechanism of 5-Fluorouracil Action -- 7 Circadian Rhythms in 5-Fluorouracil Pharmacology and Therapeutic Applications -- 8 Relevance of Scheduling to the Efficacy of 5-Fluorouracil Alone and in Combination with Other Agents -- 9 Noninvasive Studies of Fluoropyrimidines -- 10 Comparative Antitumor Activity of 5-Fluorouracil (5-FU) Prodrugs in Preclinical Model Systems: Role of Leucovorin and Dihydropyrimidine Dehydrogenase Inhibitors -- 11 Bimonthly 48-h Leucovorin and 5-Fluorouracil-Based Regimens in Advanced Colorectal Cancer -- 12 Review on the Combination of Systemic and Locoregional Treatment for Colorectal Liver Metastases -- 13 Fluoropyrimidines in Advanced Colorectal Cancer: A Review of Six Consecutive Meta-Analyses -- 14 The Mayo/NCCTG Experience with 5-Fluorouracil and Leucovorin in Adjuvant Advanced Colorectal Cancer -- 15 Fluoropyrimidines for the Adjuvant Treatment of Colorectal Cancer: The NSABP Experience -- 16 Clinical Trials of UFT Leucovorin in Gastrointestinal Malignancies -- 17 The Development of Oral UFT with and without Leucovorin -- 18 UFT in Elderly Patients with Colorectal Cancer -- 19 Clinical Trials of the Eniluracil/5-Fluorouracil Combination -- 20 Discovery and Preclinical Pharmacology of Capecitabine -- 21 Capecitabine, A Tumor-Targeting Oral Fluoropyrimidine: Molecular Rationale and Clinical Validation -- 22 Capecitabine: A Rationally Developed Anticancer Drug -- 23 Preclinical and Clinical Practice of S-1 in Japan -- 24 Preclinical and Clinical Practice of Low-Dose FP Therapy in Japan: Japanese Use of Low-Dose FP Therapy