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TitleAllogeneic Stem Cell Transplantation [electronic resource] : Clinical Research and Practice / edited by Mary J. Laughlin, Hillard M. Lazarus
ImprintTotowa, NJ : Humana Press : Imprint: Humana Press, 2003
Connect tohttp://dx.doi.org/10.1007/978-1-59259-333-0
Descript X, 454 p. online resource

SUMMARY

Allogeneic transplantation has dramatically grown in importance as a curative cellular therapy for patients with hematologic malignancies and selected solid tumors, marrow failure disorders, and inherited metabolic diseases. In Allogeneic Stem Cell Transplantation: Clinical Research and Practice, internationally recognized physicians and researchers review both the basics of allogeneic stem cell transplantation and recent advances in the field, particularly as they relate to antitumor effects and graft-vs-host disease. They also provide unique decision-tree analyses to guide clinicians in selecting and managing their allogeneic transplant patients. The innovations discussed cover a variety of areas, ranging from stem cell mobilization in normal donors, to indications for allogeneic transplantation other than hematologic malignancies, to the use of non-myeloablative conditioning regimens. The authors also explore new developments in the optimal selection of unrelated allogeneic grafts (e.g., matched unrelated donor, partially mismatched family member, or umbilical cord blood), the use allogeneic peripheral blood stem cell vs marrow-derived grafts for transplantation, and the kinetics of immune reconstitution after transplantation. Comprehensive and up-to-date, Allogeneic Stem Cell Transplantation: Clinical Research and Practice offers both clinicians and researchers concise advice on today's best clinical practice, as well as insightful analysis of the promising new lines of laboratory research that are leading to safer and more effective allogeneic transplant procedures


CONTENT

1 Hematopoietic Stem Cell Transplantation: A Historical Perspective -- 2 Allogeneic Hematopoietic Cell Transplantation for Adult Patients with Acute Myelogenous Leukemia -- 3 Allogeneic Stem Cell Transplantation for Adult Acute Lymphoblastic Leukemia -- 4 Chronic Myelogenous Leukemia -- 5 Allogeneic Stem Cell Transplantation for Breast Cancer -- 6 Allogeneic Transplantation for the Treatment of Multiple Myeloma -- 7 Non-Hodgkinโ{128}{153}s Lymphoma -- 8 Blood vs Marrow Allogeneic Stem Cell Transplantation -- 9 Haploidentical Stem Cell Transplantation -- 10 Umbilical Cord Blood Transplantation -- 11 Mesenchymal Stem Cells in Allogeneic Transplantation -- 12 Cytokines in Allogeneic Stem Cell Mobilization -- 13 Nonmyeloablative Allogeneic Transplantation -- 14 Recent Developments in Epidemiology and Management of Invasive Fungal Infections -- 15 Immune Recovery Following Allogeneic Blood Transplantation: Mechanisms of Immune Dysfunction -- 16 Grading and Management of Graft-vs-Host Disease -- 17 Posttransplant EBV-Associated Disease -- 18 Allogeneic Antitumor Vaccine Strategies -- 19 Donor Leukocyte Infusions -- 20 Second Hematopoietic Stem Cell Transplantation for the Treatment of Graft Failure, Graft Rejection, or Relapse -- 21 The Role of T Cell Depletion in Bone Marrow Transplantation -- 22 Minimal Residual Disease in Allogeneic Recipients -- 23 Nonhuman Primate Models of Hematopoietic Stem Cell Transplantation -- 24 In Vivo Models for the Study of Graft-vs-Host Disease and Graft-vs-Tumor Effects -- 25 Allogeneic Effector Cell Populations: Separating GVL from GVHD -- 26 Dendritic Cells: Immunobiology and Potential Use for Cancer Immunotherapy -- 27 Epilogue


Medicine Oncology Medicine & Public Health Oncology



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