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TitleLeukemia and Lymphoma [electronic resource] : Detection of Minimal Residual Disease / edited by Theodore F. Zipf, Dennis A. Johnston
ImprintTotowa, NJ : Humana Press : Imprint: Humana Press, 2003
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Descript XII, 257 p. online resource


With the detection of the leukemias and lymphomas at levels almost four orders of magnitude below that obtainable by light microcopy, the groundwork has been laid for the development of reliable clinical tools and a redefinition of remission and relapse. In Leukemia and Lymphoma: Detection of Minimal Residual Disease, hands-on experts describe and discuss the minimal residual disease (MRD) methods they have successfully pioneered for these hematological cancers. The techniques range from the use of patient-specific immunophenotypes to identify residual leukemia in patients who are in remission, to a variety of PCR techniques for detecting residual disease and measuring its level. Reverse transcription PCR (RT-PCR) is applied to acute myeloid leukemia (AML), chronic myelogenous leukemia (CML), and acute promyelocytic leukemia (APL). Other PCR methods are used for non-Hodgkin's lymphoma and for the monitoring of follicular lymphoma. Additional chapters address the use of real-time quantitative PCR (RQ-PCR), the emergent method of choice, in patients with acute lymphoblastic leukemia (ALL), the evaluation of MRD techniques in clinical trials, and the application of flow cytometry techniques. Comprehensive and innovative, Leukemia and Lymphoma: Detection of Minimal Residual Disease sets the stage for implementing the new standard detection and quantitation techniques as reliable tools for clinical decision-making, as well as for improved predictions and treatment outcomes


1 Flow-Cytometry Methods for the Detection of Residual Leukemia -- 2 Flow-Cytometryโ{128}{148}Based Studies of Minimal Residual Disease in Children with Acute Lymphoblastic Leukemia -- 3 PCR Methods for the Detection of Minimal Residual Disease in Childhood Acute Lymphoblastic Leukemia -- 4 Statistical Considerations in the Analysis of Minimal Residual Disease -- 5 The Application of Minimal Residual Disease Detection Methodology to the Clinical Decision-Making Process -- 6 Measurement of Minimal Residual Disease in Children Undergoing Allogeneic Stem Cell Transplant for Acute Lymphoblastic Leukemia -- 7 Molecular Investigation of Minimal Residual Disease in Adult Acute Lymphoblastic Leukemia of B Lineage -- 8 Investigation of Minimal Residual Disease in Acute Myeloid Leukemia by Immunophenotyping -- 9 Minimal Residual Disease in Acute Myeloid Leukemia: RT-PCRโ{128}{148}Based Studies of Fusion Transcripts -- 10 Minimal Residual Disease in Acute Promyelocytic Leukemia -- 11 Minimal Residual Disease in Chronic Myelogenous Leukemia: Results of RT-PCR Detection of BCR-ABL Transcripts -- 12 Utility of PCR Assessment of Minimal Residual Disease After Stem Cell Transplantation in Non-Hodgkinโ{128}{153}s Lymphoma -- 13 Real-Time Polymerase Chain Reaction of Genomic DNA for Quantitation of t(14;18) -- 14 Monitoring Follicular Lymphoma by Polymerase Chain Reaction -- 15 Editorsโ{128}{153} Notes

Medicine Hematology Medicine & Public Health Hematology


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