Title | COX-2 Blockade in Cancer Prevention and Therapy [electronic resource] / edited by Randall E. Harris |
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Imprint | Totowa, NJ : Humana Press : Imprint: Humana Press, 2003 |
Connect to | http://dx.doi.org/10.1007/978-1-59259-302-6 |
Descript | X, 371 p. online resource |
I. Historical Perspectives -- l Dietary Fatty Acids, COX-2 Blockade, and Carcinogenesis -- 2 Historical Aspects of COX-2: Cloning and Characterization of the cDNA, Protein and Gene -- II. Epidemiology of NSAIDS and Cancer -- 3 Epidemiology of Nonsteroidal Anti-Inflammatory Drugs and Colorectal Cancer -- 4 Epidemiology of Breast Cancer and Nonsteroidal Anti-Inflammatory Drugs: Extension of the Dietary Fat Hypothesis of Breast Cancer -- III. Animal Models of Carcinogenesis -- 5 Role of Synthetic and Naturally Occurring Cyclooxygenase Inhibitors in Colon Cancer Prevention -- 6 Chemoprevention of Breast Cancer by Nonsteroidal Anti-Inflammatory Drugs and Selective COX-2 Blockade in Animals -- 7 The Role of Cyclooxygenase-2 in the Prevention and Therapy of Lung Cancer -- 8 Nonsteroidal Anti-Inflammatory Drugs, Prostaglandins, and Apc-Driven Intestinal Tumorigenesis -- 9 Cyclooxygenase-1 and Cyclooxygenase-2 Knockout Mice Provide Insights into Beneficial and Adverse Effects of Nonsteroidal Anti-Inflammatory Drugs -- IV. Molecular Biology of CXO -- 10 Cyclooxygenase-2, Prostaglandins, and Colorectal Carcinogenesis -- 11 Regulation of Expression and Potential Carcinogenic Role of Cyclooxygenase-2 -- 12 Cyclooxygenase-2 and Cancer -- 13 Interactions of Cyclooxygenase and Aromatase Pathways in Normal and Malignant Breast Cells -- 14 Association of COX-2 and PPARs in Carcinogenesis and Chemoprevention -- 15 Carcinogenesis Involving Cyclooxygenase and Lipoxygenase -- V. Clinical Applications -- 16 The Development of Drugs that Target Cyclooxygenase-2 -- 17 Chemoprevention of Cancer by NSAIDs and Selective COX-2 Blockade -- 18 Potential for Inhibitors of Cyclooxygenase-2 to Enhance Tumor Radioresponse -- 19 Potential Role of NSAIDs and COX-2 Blockade in Cancer Therapy -- 20 Cyclooxygenase-2 Blockade in Cancer Prevention and Therapy: Widening the Scope of Impact