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TitleOsteoporosis [electronic resource] : Pathophysiology and Clinical Management / edited by Eric S. Orwoll, Michael Bliziotes
ImprintTotowa, NJ : Humana Press : Imprint: Humana Press, 2003
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Descript XI, 615 p. online resource


With varying degrees of osteoporosis found in one of every four women older than 45 years of age and in nine out of ten women older than 75, as well as in men, osteoporosis is clearly a widespread disease with important health and economic impacts. It is also scientifically complex. In Osteoporosis: Pathophysiology and Clinical Management, leading clinicians and researchers join forces to illuminate in coupled chapters all the major scientific and clinical aspects of osteoporosis. By uniquely coupling basic and clinical chapters, the book illustrates the critical interdependence of investigators and practitioners. Traditional issues such as calcium supplementation and exercise are juxtaposed with state-of-the-art updates on molecular pharmacology and imaging. On the basic science side, topics range from the genetics of osteoporosis and bone turnover markers, to androgen action in bone, to the basic biology of estrogen and bone. On the clinical side the authors present the latest thinking about the use of bone densitometry in treatment, the use of vitamin D and its metabolites, and the clinical utilization of salmon calcitonin, as well as parathyroid and bisphosphonate therapies, SERMs, and other important treatments. Unique in its integration of basic science and clinical practice, Osteoporosis: Pathophysiology and Clinical Management reveals the great progress that has occurred in the field, providing basic scientists with a clear view of the clinical state-of-the-art, and practicing physicians with a deeper understanding of the complex biology involved


1 Human and Animal Studies of the Genetics of Osteoporosis -- 2 The Genetics of Osteoporosis: Progress in Mice, not Man -- 3 Peak Bone Mass Acquisition -- 4 Peripheral Bone Mineral Assessment of the Axial Skeleton: Technical Aspects -- 5 Use of Bone Densitometry in the Clinical Management of Osteoporosis -- 6 Technical Aspects of Skeletal Assessment Using Quantitative Ultrasound -- 7 Clinical Aspects of Skeletal Assessment with Ultrasound -- 8 Molecular Markers of Bone Turnover: Basic and Analytical Aspects -- 9 Bone Turnover Markers: Their Place in the Investigation of Osteoporosis -- 10 Mechanical Influences on Bone Mass and Morphology: Investigating How Exercise May Regulate Adaptation in the Skeleton -- 11 Exercise in the Prevention of Osteoporosis-Related Fractures -- 12 The Physiology and Cell Biology of Calcium Transport in Relation to the Development of Osteoporosis -- 13 Calcium, Bone, and Life -- 14 Clinical Aspects of the Use of Vitamin D and Its Metabolites in Osteoporosis -- 15 The Basic Biology of Estrogen and Bone -- 16 Clinical Trials of Estrogen and SERMs on Bone Markers, Bone Mineral Density, and Fractures -- 17 Androgen Action in Bone: Basic Cellular and Molecular Aspects -- 18 Androgens and Skeletal Homeostasis: Potential Clinical Implications of Animal Data -- 19 Gonadal Steroids and the Skeleton in Men: Clinical Aspects -- 20 Basic Aspects of Calcitonin in Skeletal Health -- 21 Clinical Utilization of Salmon Calcitonin in the Treatment of Osteoporosis: Rationale, Supportive Data, and Considerations for the Future -- 22 The Mechanism of Action of Nitrogen-Containing Bisphosphonates -- 23 Bisphosphonate Treatment of Osteoporosis -- 24 Basic Aspects of PTH in Skeletal Health -- 25 Parathyroid Hormone as a Therapy for Osteoporosis -- 26 The Cellular and Molecular Aspects of Immunosuppressant Osteoporosis -- 27 Transplantation Osteoporosis -- 28 The Molecular Pharmacology of Osteoporosis

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