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TitleEndocrine Oncology [electronic resource] / edited by Stephen P. Ethier
ImprintTotowa, NJ : Humana Press : Imprint: Humana Press, 2000
Connect tohttp://dx.doi.org/10.1007/978-1-59259-223-4
Descript XII, 396 p. online resource

SUMMARY

Cancers of endocrine tissues are an increasingly important public health concern whose growing prevalence has made them the focus of intensive research in recent years. In Endocrine Oncology, Stephen P. Ethier and a panel of leading investigators comprehensively analyze the cellular, molecular, and endocrine factors involved in the development of cancers of the breast, prostate, endometrium, and ovary. Concentrating on defining the most important unresolved issues in the field, the authors review how steroid hormones function to regulate normal mammary gland homeostasis in humans, with particular emphasis on the roles of estrogen, progesterone, and growth factors. Also examined are the effects of steroids in prostate cancer development and treatment, the function of growth factors in endocrine neoplasia, the actions of such nonsteroid hormones as prolactin, and the role of the suppressor genes BRCA1 and BRCA2. Throughout the book, the clinical relevance of scientific findings is emphasized. Comprehensive and up-to-date, Endocrine Oncology offers both basic and clinical researchers not only the latest molecular and cellular findings on endocrine cancers, but also a powerful critical analysis that will prove invaluable to all endocrinologists and oncologists working in the area today


CONTENT

1 Estrogen Receptor in Mammary Gland Physiology -- 2 Multiple Facets of Estrogen Recptor in Human Breast Cancer -- 3 Progesterone Receptors in Normal and Neoplastic Breast -- 4 Pathogenesis of Estrogen Receptor-Positive and โ{128}{147}Negative Breast Cancer -- 5 Regulation of EGFR and ERBB2 Expression by Estrogen Receptor in Breast Cancer -- 6 Tamoxifen and Other Antiestrogens in Prevention and Therapy of Breast Cancer -- 7 Prolactin in Human Breast Cancer Development -- 8 Human Chorionic Gonadotropin in Breast Cancer Prevention -- 9 Epidermal Growth Factor-Related Peptides in Endocrine Neoplasias -- 10 Insulin-Like Growth Factors and Endocrine Neoplasia -- 11 Insulin-Like Growth Factor Binding Proteins in Endocrine-Related Neoplasia -- 12 Fibroblast Growth Factors and Their Receptors in Breast and Prostate Cancer -- 13 Steroid Receptors in Prostate Cancer Development and Progression -- 14 Type I Family Growth Factor Receptors and Their Ligands in Prostate Cancer -- 15 Hormonal Manipulation of Prostate Cancer -- 16 Endocrinology of Epithelial Ovarian Cancer -- 17 Molecular Pathogenesis of Endometrial Cancer: The Role of Tamoxifen -- 18 Structure and Function of BRCA Genes -- 19 Role of Apoptosis and its Modulation by Bc1-2 Family Members in Breast and Prostate Cancer -- 20 Transcriptional Coactivators in Cancer


Medicine Endocrinology Oncology Medicine & Public Health Endocrinology Oncology



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