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TitlePrinciples of Molecular Oncology [electronic resource] / edited by Miguel H. Bronchud, Mary Ann Foote, William P. Peters, Murray O. Robinson
ImprintTotowa, NJ : Humana Press : Imprint: Humana Press, 2000
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Descript XVI, 452 p. online resource


"...provides a bold new look at the evolution of our knowledge of cancer...will prove both informative and intellectually satisfying." -- E. Donnall Thomas, MD "...[an] excellent book... -- Professor Sir David J. Weatherall, FRS, Regius Professor of Medicine, University of Oxford In Principles of Molecular Oncology, award winning basic scientists and clinical researchers summarize the wealth of new molecular knowledge that sees cancer as a "disease process" involving key regulatory pathways. Emphasizing prevention, early diagnosis, prognosis, and treatment, these authoritative experts from around the world illuminate the variety of molecular markers to be found, interpret what is known about diseased regulatory pathways, and examine those future research directions likely to realize the promise of molecular therapy. From their presentations, readers will gain an understanding of why current therapies work or fail, and of the new processes now available to identify specific molecular targets for optimal therapeutic efficacy. Rational therapies designed to target metastatic progression are also critically reviewed. Comprehensive and pathbreaking, Principles of Molecular Oncology offers both basic and clinical oncologists not only a bold synthesis of the rapid and complex advances in molecular biology that are transforming our knowledge of cancer, but also a highly practical guide to today's best strategies for its diagnosis and treatment


1 Selecting the Right Targets for Cancer Therapy -- 2 Clinical Importance of Prognostic Factors: Moving from Scientifically Interesting to Clinically Useful -- 3 Genetic Markers in Sporadic Tumors -- 4 Cellular and Tissue Markers in Solid Tumors -- 5 Circulating Tumor Markers -- 6 Growth Factor-Signaling Pathways in Cancer -- 7 Estrogen Action and Breast Cancer -- 8 Cyclin-Dependent Kinases and Their Regulators as Potential Targets for Anticancer Therapeutics -- 9 Apoptosis Pathways: Clinical Relevance -- 10 DNA Repair Pathways: Mechanisms and Defects in the Maintenance of Genome Stability -- 11 Angiogenesis Switch Pathways -- 12 Invasion and Metastasis -- 13 Molecular Pathways of Drug Resistance -- 14 Antitumor Immunity as Therapy for Human Cancer -- 15 Emerging Technologies: Molecular Targets and the Drug Delivery Process -- 16 Emerging Molecular Therapies for Cancer -- 17 Emerging Molecular Therapies: Small-Molecule Drugs

Medicine Oncology Medicine & Public Health Oncology


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