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TitleGene Engineering in Endocrinology [electronic resource] / edited by Margaret A. Shupnik
ImprintTotowa, NJ : Humana Press : Imprint: Humana Press, 2000
Connect tohttp://dx.doi.org/10.1007/978-1-59259-221-0
Descript XII, 428 p. online resource

SUMMARY

Recent advances in genetic engineering and molecular biology have made it possible to disrupt specific genes in order to determine and better understand their function and clinical significance. In Gene Engineering in Endocrinology, Margaret Shupnik and a team of leading investigators review the most recent breakthroughs, emphasizing how studies of natural mutations and gene knockouts have illuminated endocrine processes. Using both animal and human model data, these authoritative researchers examine in depth the molecular basis of development, growth, and reproductive processes, the specific mutations that explain certain genetic syndromes, the hormonal regulation of gene expression (which affects the treatment of infertility and steroid-dependent cancers), and current research directions. When possible, molecular studies are compared with naturally occurring human and animal gene mutations to establish the difference between complete elimination of, or an altered, gene function. Comprehensive and up-to-date, Gene Engineering in Endocrinology offers today's experimental and clinical endocrinologists, as well as reproductive biologists, a richly informative survey of what has already been accomplished with the genetic engineering of hormone processes and hormone-related genetic syndromes-research that promises powerful new experimental and therapeutic opportunities as this field continues it rapid development


CONTENT

I Growth, Development, and Metabolism -- 1 Differential Cell Signaling and Gene Activation by the Human Growth Hormone Receptor: From Cell Surface to Cell Nucleus -- 2 Insulin Action: Molecular Mechanisms and Determinants of Specificity -- 3 Ets Transcription Factors: Nuclear Integrators of Signaling Pathways Regulating Endocrine Gene Expression and Carcinogenesis -- 4 Pit-1 Expression, Regulation, and Modulation of Multiple Pituitary Genes -- 5 Subnuclear Trafficking of Glucocorticoid Receptors: General Mechanisms and Specific Recruitment to a Unique Target Site by Tethering to a DNA-Bound POU Domain Protein -- 6 Thyroid Hormone Receptors and Their Multiple Transcriptional Roles -- 7 Models of Resistance to Thyroid Hormone -- 8 Thyroid Hormone Receptor Family Members: Homodimers, Heterodimers, and Mechanisms of Transcriptional Repression -- 9 SF-1 and DAX-1: A Dynamic Duo in Endocrine Development -- II Reproductive System -- 10 Gene Knockout Models to Study the Hypothalamus-Pituitary-Gonadal Axis -- 11 Transgenic Approaches to Study Developmental Expression and Regulation of the Gonadotropin Genes -- 12 Molecular Events Defining Follicular Developments and Steroidogenesis in the Ovary -- 13 Regulation of Inhibin Subunit Gene Expression by Gonadotropins and cAMP in Ovarian Granulosa Cells -- 14 Placental Trophoblast Cells: Transcriptional Regulation and Differentiation -- 15 Alternative Splicing of mRNAs for cAMP-Responsive Transcriptional Factors and Modulation of Gene Transcription in the Testis -- 16 The Androgen Receptor, Androgen Insensitivity, and Prostate Cancer -- 17 Genetic Determination of Androgen Responsiveness -- 18 Steroid Receptor Regulation by Phosphorylation and Cell Signaling Pathways -- 19 Steroid Receptor Actions: Agonists and Antagonists and the Role of Coactivators and Corepressors


Medicine Endocrinology Medicine & Public Health Endocrinology



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