Recent advances in molecular endocrinology have significantly increased our understanding of endocrine diseases, as well as that of the medical management of these complicated disorders. In Developmental Endocrinology: From Research to Clinical Practice, leading researchers comprehensively translate all the latest scientific information regarding endocrine physiology and development into an understanding of the clinical pathogenesis, diagnosis, and treatment of these diseases. Organized by endocrine system, each section of the book concisely describes the chronological development of the human organism, from the fetal/prenatal period through childhood, adolescence, and, in some cases, into adulthood. The prenatal sections review recent discoveries concerning transcription factors, homeobox genes, and human molecular mutations- the basic processes governing prenatal development of the individual endocrine organs--and detail the pathophysiology, clinical characteristics, and treatment of pediatric endocrine disorders. Authoritative, comprehensive, and readily accessible, Developmental Endocrinology: From Research to Clinical Practice illuminates for today's medical investigators, basic scientists, and clinicians our rapidly emerging understanding of this complex field, as well as constituting an invaluable guide to the practical clinical management of endocrine diseases
CONTENT
I Hypothalamus/Pituitary -- 1 Transcriptional Control of the Development and Function of the Hypothalamic-Pituitary Axis -- II Growth -- 2 Molecular Mutations in the Human Growth Hormone Axis -- 3 Normal and Abnormal Growth -- 4 Adult Growth Hormone Deficiency -- III Thyroid -- 5 Molecular Mechanisms of Thyroid Gland Development: Insights from Clinical Studies and from Mutant Mice -- 6 Fetal-Perinatal Thyroid Physiology -- 7 Thyroid Disorders in Children and Adolescents -- IV Calcium and Bone -- 8 Genetic Control of Parathyroid Gland Development and Molecular Insights into Hypoparathyroidism -- 9 Bone Physiology -- 10 Pediatric Bone Disease -- V Gonadal Development -- 11 Transcriptional Development of the Hypothalamic-Pituitary-Gonadal Axis -- 12 Sexual Differentiation -- 13 Prenatal Androgens and Sexual Differentiation of Behavior -- 14 Normal and Precocious Puberty -- 15 Delayed Puberty -- VI Adrenal -- 16 Molecular Development of the Hypothalamic-Pituitary-Adrenal (HPA) Axis -- 17 Molecular Genetics of Adrenal Disease
