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TitleThe Molecular Basis of Human Cancer [electronic resource] / edited by William B. Coleman, Gregory J. Tsongalis
ImprintTotowa, NJ : Humana Press : Imprint: Humana Press, 2002
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Descript XII, 588 p. online resource


Molecular biology holds great promise for the development of new strategies for cancer prevention and treatment. In The Molecular Basis of Human Cancer, internationally renowned basic and clinical scientists provide an account of our best current understanding of the genetics of cancer. These authoritative contributors describe in detail each of the known molecular mechanisms governing neoplastic transformation in the breast, prostate, lung, liver, colon, skin, and in the leukemias and lymphomas. Their discussion illuminates both recent developments and established concepts in epidemiology, molecular techniques, oncogenesis, and mutation mechanisms, as well as the chemical, viral, and physical mechanisms of cancer induction. They also consider the future directions of research, including discussions of the exploitation of molecular targets for developing anticancer drugs, recent developments in gene therapy, and the appropriate use of molecular information in genetic counseling. Up-to-date and forward-looking, The Molecular Basis of Human Cancer offers a critically integrated survey of the full range of state-of-the-art cancer molecular biology and genetics and constitutes indispensable reading for all cancer researchers today


I. Introduction -- 1 Cancer Epidemiology: Incidence and Etiology of Human Neoplasms -- II. Essential Concepts in Molecular Biology -- 2 Essential Concepts and Techniques in Molecular Biology -- III. Molecular Themes in Oncogenesis -- 3 Cancer Genes -- 4 Positive Mediators of Cell Proliferation in Neoplastic Transformation -- 5 Inactivation of Negative Growth Regulators During Neoplastic Transformation -- IV. Mechanisms of Mutation -- 6 The Role of Genomic Instability in the Development of Human Cancer -- 7 Chromosomes and Chromosomal Instability in Human Cancer -- 8 Hereditary Cancer -- V. Etiology of Human Cancers -- 9 Evolution of Research in Cancer Etiology -- 10 Cellular Responses to Chemical Carcinogens -- 11 Physical Agents in Human Carcinogenesis -- 12 Viral Mechanisms of Human Carcinogenesis -- VI. Human Tumor Systems -- 13 The Molecular Biology of Colorectal Carcinoma: Importance of the Wg/Wnt Signal Transduction Pathway -- 14 Molecular Genetic Alterations in Primary Hepatocellular Neoplasms: Hepatocellular Adenoma, Hepatocellular Carcinoma, and Hepatoblastoma -- 15 The Molecular Basis of Breast Carcinogenesis -- 16 The Molecular Basis of Prostate Carcinogenesis -- 17 The Molecular Basis of Lung Carcinogenesis -- 18 The Molecular Basis of Skin Carcinogenesis -- 19 The Molecular Biology of Leukemias -- 20 Molecular Genetic Applications to the Diagnosis of Non-Hodgkinโ{128}{153}s Lymphoma -- VII. Future Directions -- 21 Cancer Genetic Counseling -- 22 Molecular Genetic Diagnosis of Inherited Cancer Predisposition -- 23 Novel Molecular Targets for Cancer Drug Discovery -- 24 Gene Therapy in the Treatment of Human Cancer

Medicine Oncology Medicine & Public Health Oncology


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