With over ten million diagnosed patients and another five million undiagnosed, diabetes mellitus and its complications-cardiovascular disease, nephropathy, neuropathy, and retinopathy-is a major public health problem that will assume epidemic proportions as the population grows older. In Diabetes and Cardiovascular Disease, Michael T. Johnstone, md, and Aristidis Veves, md, dsc, have assembled a panel of seasoned clinicians and expert scientists to comprehensively review both the clinical and scientific aspects of diabetic cardiovascular disease. The contributors thoroughly discuss the mechanisms and risk factors of diabetes in relation to hypertension, dyslipidemia, thrombosis, atherosclerosis, coronary artery disease, and congestive heart failure. Their review includes a full examination of the epidemiology, mechanisms, methods of assessment, and treatment of the disease at the macrovascular level, and a discussion of its microvascular effects, including retinopathy, nephropathy, neuropathy, and compromised microcirculation in the diabetic foot. Each chapter covers its topics in great detail and is accompanied by extensive references. Comprehensive and up-to-date, Diabetes and Cardiovascular Disease offers not only practicing physicians the day-to-day practical knowledge needed to treat patients effectively, but also clinical scientists a deeper understanding for developing novel therapies for this devastating illness
CONTENT
I Pathophysiology -- 1 The Metabolic Syndrome and Vascular Disease -- 2 Effects of Insulin on the Vascular System -- 3 Effect of Diabetes on Endothelial Function -- 4 Vascular Abnormalities in the Prediabetic State -- 5 Diabetes and Advanced Glycation End Products -- 6 The Reninโ{128}{148}Angiotensin System in Diabetic Cardiovascular Complications -- 7 Diabetes and Hypertension -- 8 Diabetes and Dyslipidemia -- 9 Diabetes and Thrombosis -- 10 Diabetes and Atherosclerosis -- 11 Animal Models of Diabetes and Atherosclerosis -- 12 Nitric Oxide and Its Role in Diabetes Mellitus -- 13 Plasminogen Activator Inhibitor-1 and Vascular Disease in Diabetes Mellitus -- II The Heart -- 14 Coronary Artery Disease in Diabetes -- 15 Heart Failure in Diabetic Patients -- 16 Preoperative Assessment and Perioperative Management of the Surgical Patient with Diabetes Mellitus -- III Peripheral Vascular System -- 17 Epidemiology of Peripheral Vascular Disease -- 18 Diabetes and Arterial Stiffness -- 19 Methods for Assessing Large Vessel Pathophysiology -- 20 Peripheral Vascular Disease in Patients with Diabetes Mellitus -- IV Microcirculation -- 21 Diabetic Retinopathy -- 22 Diabetes and Nephropathy -- 23 Vascular Changes and Diabetic Neuropathy -- 24 Microcirculation of the Diabetic Foot
