During the past thirty years, great progress has been made in defining the roles of steroid, peptide, and polypeptide hormones in the processes of lung morphogenesis, differentiation of specialized cell types, and surfactant synthesis. In Endocrinology of the Lung, Carole Mendelson has assembled a panel of leading investigators to critically review the roles of various classes of endocrine, paracrine, and neuroendocrine factors in the regulation of lung development and surfactant production. Special attention is accorded the actions of glucocorticoids in lung branching morphogenesis and the synthesis of surfactant glycerophospholipids and proteins. Also extensively examined are the roles of cell-cell interactions and the elaboration of various growth factors and bioactive peptides in pulmonary cell differentiation, gene expression, and pathophysiology. The model systems utilized in these studies range from whole animal to transgenic and gene-targeted mice, to organ and cell culture. State-of-the-art and comprehensive, Endocrinology of the Lung constitutes a powerful new standard guide that illuminates the complex endocrinology of the lung for investigators actively studying hormone action in pulmonary biology and medicine today
CONTENT
1 The Glucocorticoid Domain in the Lung and Mechanisms of Action -- 2 Fetal Responses to Glucocorticoids -- 3 Cyclic Adenosine Monophosphate and Glucocorticoid Regulation of Surfactant Protein-A Gene Expression -- 4 Hormonal Regulation of Surfactant Protein-B and Surfactant Protein-C Gene Expression in Fetal Lung -- 5 Glucocorticoid Regulation of Fatty Acid Synthase in Fetal Lung -- 6 The Genetics of Glucocorticoid-Regulated Embryonic Lung Morphogenesis: A First Approximation of the Epigenetic Rules -- 7 Corticotropin-Releasing Hormone and the Lung -- 8 Sex Differences in Fetal Lung Development: Biology, Etiology, and Evolutionary Significance -- 9 Retinoids and Lung Development -- 10 Insulin and Lung Development -- 11 The Insulin-like Growth Factor System and Lung -- 12 Platelet-Derived Growth Factor and Lung Development -- 13 Transforming Growth Factor-? Receptor Signaling and Lung Development -- 14 Transgenic Mouse Models for the Study of Growth Factor Signaling During Lung Morphogenesis -- 15 Parathyroid Hormone-Related Protein -- 16 Role of Neuroendocrine Cells in Fetal and Postnatal Lung
