Structure and โ{128}{148} Function โ{128}{148} -- Embryology and physiopathology of early pregnancy trophoblast -- Fine structure of chorionic tissue in health and disease -- The enzymology of chorionic villi and the first trimester diagnosis of metabolic disorders -- Placental immunobiology in early pregnancy -- Transcervical Chorion โ{128}{148} Villus Sampling โ{128}{148} -- The method of chorion villus sampling under real-time ultrasound guidance using the โ{128}{152}Portexโ{128}{153} cannula -- Transcervical chorion villus aspiration by a single operator technique -- Tipped metal cannulae -- The Nottingham brush for chorion villus sampling -- Chorion villus sampling using rigid forceps -- Blind chorion villus aspiration -- Ultrasound for transcervical chorion villus sampling -- Is ultrasound guidance necessary for successful transcervical chorion villus sampling? -- Endoscopic chorion villus sampling -- Danish experience -- Development and clinical application -- Clinical Applications -- Pregnancy outcome and the need for centralized data collection in chorion villus sampling -- Evaluation of the long-term consequences of chorion villus sampling -- Early prenatal diagnosis and therapeutic potentials for the fetus -- Early prenatal diagnosis and fetal surgery -- Towards a chorion villus sampling service -- Chorion villus sampling for direct chromosomal analysis in a non-teaching hospital -- The economic efficiency of prenatal screening -- Chromosomes and DNA โ{128}{148} Analysis โ{128}{148} -- Prenatal karyotyping: amniotic fluid cells or chorion villus samples? -- Chorionic villi and direct chromosome preparation -- Cytoculture of chorionic tissue -- Recombinant DNA technology and prenatal diagnosis -- Genetic engineering and detection of haemoglobinopathies -- Extraction of DNA from chorionic villi -- Genetic Counselling -- Counselling in prenatal diagnosis -- Chorion villus sampling in X-linked genetic disorders