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TitlePlatinum and Other Metal Coordination Compounds in Cancer Chemotherapy 2 [electronic resource] / edited by H. M. Pinedo, J. H. Schornagel
ImprintBoston, MA : Springer US : Imprint: Springer, 1996
Connect tohttp://dx.doi.org/10.1007/978-1-4899-0218-4
Descript X, 358 p. online resource

CONTENT

Synthesis and Activity of Platinum Compounds -- NMR Spectroscopy of Platinum Drugs: From DNA to Body Fluids -- Trans-Diamminedichloroplatinum (II) Is Not an Antitumor Drug: Why? -- Iminoethers as Carrier Ligands: A Novel trans-Platinum Complex Possessing in Vitro and in Vivo Antitumor Activity -- Molecular Dynamics Simulations on Cisplatin Adducts with Dinucleotides -- Orally Active DACH-Pt (IV) Compounds -- Clinical Pharmacology -- Pharmacokinetic โ{128}{148} Pharmacodynamic Relationships -- Clinical Pharmacology of Carboplatin Administered in Alternating Sequence with Paclitaxel in Patients with Non-Small Cell Lung Cancer: A European Cancer Centre (ECC) Study -- The Clinical Development of the Oral Platinum Anticancer Agent JM216 -- Biochemistry and Molecular Pharmacology -- Membrane Transport of Platinum Compounds -- Detection of Adducts Formed upon Treatment of DNA with Cisplatin and Carboplatin -- Detection of Platinum Lesions at the Nucleotide Level in Cells using Single Strand Ligation PCR -- A Review of the Modulation of Cisplatin Toxicities by Chemoprotectants -- Combination Therapy with Cisplatinum and EGF Receptor Blockade -- Clinical Studies -- Oxaliplatin: Update on a Active and Safe Dach Platinum Complex -- Combination of Different Platinum Compounds: Issues, Strategies and Experience -- Phase I and II Studies with Lobaplatin -- Phase I Trials of Ormaplatin (NSC 363812) -- 254-S, NK121 and TRK710 -- Clinical Trials of Oxaliplatin and DWA2114R -- Incorporating Assessments of Sequence-Dependence in Developmental Studies of Combination Chemotherapy Regimens Containing New Agents and Platinum Compounds -- Review of Carboplatin-Based High-Dose Chemotherapy Combinations in the Autotransplant Setting -- Treatment Intensification in Germ-Cell Tumours -- IL-1? Enhancement of Platinum-Mediated Anti-Tumor Activity -- Non-Platinum Metal Complexes -- Overview of Tumor-Inhibiting Non-Platinum Complexes -- How does Platinum Kill the Cell? -- The Cisplatin-Induced Cellular Injury Response -- The Interaction of Cisplatin with Signal Transduction Pathways and the Regulation of Apoptosis -- Cell Cycle Checkpoints and Cancer Chemotherapy -- Controversy Session: Cisplatin vs Carboplatin? -- Carboplatin versus Cisplatin in the Chemotherapy of Solid Tumors: Pro-Carboplatin -- Cisplatin and Carboplatin in Testis and Ovarian Cancer: Pro Cisplatin -- Resistance -- Hypersensitivity to Cisplatin in Mouse Leukemia L1210/0 Cells: An XPG DNA Repair Defect -- DNA Repair and the Carrier Ligand Specificity of Platinum Resistance -- Transcription Factor Differences in Cisplatin Resistant Cells


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