Title | Chemists' Views of Imaging Centers [electronic resource] / edited by Ali M. Emran |
---|---|
Imprint | Boston, MA : Springer US : Imprint: Springer, 1995 |
Connect to | http://dx.doi.org/10.1007/978-1-4757-9670-4 |
Descript | XIV, 538 p. online resource |
Technical, Administrative and Organizational Issues in Clinical PET -- 1.1. The Role of Chemists in Developing Radiopharmaceutical Applications, Industry and Regulations: Introductory Remarks -- 1.2. The Basics of Positron Emission Tomographic (PET) Imaging -- 1.3. PET: A Biochemical and Physiological Measuring Modality -- 1.4. Layout and Planning of a University Hospital Clinical Cyclotron/PET Facility -- 1.5. Evaluating The UTMCK PET Center: An Organizational and Financial Analysis -- 1.6. The European Concerted Action in PET: Activities in Radiochemistry -- 1.7. Pharmacy Practice and PET -- Regulatory Issues in Clinical PET -- 2.1. Clinical Imaging Centers: The Role of State Radiation Control Programs -- 2.2. PET: The Governmental Reimbursement Perspective -- 2.3. Review of Radiopharmaceutical IND's and NDA's -- 2.4. Compliance with Good Manufacturing Practice -- 2.5. The Regulatory Process: The Institute for Clinical PET's Experience -- 2.6. USP Activities and PET Radiopharmaceuticals -- 2.7. Managing the Obstacles in the Path of Regulatory Approval of PET -- Pet Related Equipments Specifications and Selection -- 3.1. Laboratory and Cyclotron Requirements for PET Research -- 3.2. Truly Frugal PET: Is It Possible? -- 3.3. RFQ's for PET Radionuclide Production -- 3.4. Strategies in Synthesizing Short-Lived Radiopharmaceuticals for PET -- Quality Assurance/Quality Control and Related Issues -- 4.1. Role of Current Good Manufacturing Practices in Establishment of Quality Assurance for In-House Radiopharmaceuticals -- 4.2. Quality Control for 11C and 18F Radiopharmaceuticals in the Research Environment -- 4.3. Trend Analysis of Quality Control Data -- 4.4. Quality Assurance of Radiolabelled Proteins, Peptides and Anti-Sense Oligonucleotides -- 4.5. Reactor Isotope Quality Assurance -- 4.6. Analytical Instrumentation in the QC of PET Radiopharmaceuticals -- Radiopharmaceuticals for Biomedical Research and Imaging -- 5.1. Development and Production of Radiopharmaceuticals for PET -- 5.2. New PET Tracers for Cerebral Dopamine: Should 6-[18F]-Fluoro-L-Dopa Be Replaced? -- 5.3. Design, Structure-Activity, Labelling and Purity in Development of Receptor Interacting Radiohalogenated Tracers -- 5.4. Halogenated Benzamides as Ligands for Cerebral Dopamine Receptors -- 5.5. Development of Fluorine-18 Radiopharmaceuticals for Dopamine Neuroreceptors -- Applications of Various Nuclides -- 6.1. Radionuclides and Their Applications in Oncology Research -- 6.2. Positron Emitting Radiotracers for in vivo Plant Research -- 6.3. Production and Applications of 123I-Labelled meta-Iodobenzylguanidine (123I-mIBG) -- 6.4. Chemistry, Radiochemistry and Applications of Potassium Isotopes -- 6.5. 19F-MR Characterization of Fluorinated Proteins and Relaxation Rate Enhancement with Gd-DTPA for Faster Imaging -- 6.6. Recovery of Bi-213 from an Ac-225 Cow: Application to the Radiolabelling of Antibodies with Bi-213 -- Targetry and Precursor Chemistry -- 7.1. Application of Fullerenes in Biomedical Imaging -- 7.2. High Pressure H218O Target for the Production of [18F]-Fluoride Ion -- 7.3. Requirements for Production Targets for Middle-Energy Cyclotrons -- 7.4. Synthesis of Fluorine-18 Labelled Compounds for Brain Imaging -- 7.5. Solid Phase Reagents in Radiosynthesis -- Radiotracer Syntheses -- 8.1. Flourine-18 Labeling of Radiopharmaceuticals for PET Studies: Main Aspects and Problems Encountered in Chemical Synthesis -- 8.2. Distribution and Quantification of 18F-Activity Produced via 20Ne(d,?)18F Reaction in a Gas Target -- 8.3. Twenty Years as a Chemist in the Service of a PET Center -- 8.4. Clinical Blood Flow Measurements with 15O-H2O and Positron Emission Tomography (PET) -- 8.5. Radiofluorinated Enzyme Probes of Dopaminergic Function -- 8.6. Routine Production of [18F]-F2 from 11 MeV Proton-Only Cyclotron and Its Use for 18F-Tracers for Heart and Brain -- Automated Synthesis of Radiotracers -- 9.1. The Hammersmith Philosophy for PET Chemistry Automation -- 9.2. The Use of Microwaves for the Automated Production of Radiopharmaceuticals -- 9.3. Reverse Robotics: Interactive Machines for Controlling People in a Complex Laboratory Environment -- 9.4. Automated Radiochemistry through Transducers: Light from the Far Side -- Chiral Syntheses and Separations -- 10.1. Homochiral Radioligands for PET: Aspects of Asymmetric Synthesis, Analysis and Behavior in Vivo -- 10.2. Fluorinated Tropinyl Esters for Application with PET -- 10.3. Preparation and Examination of Labeled Stereoisomers in Vivo by PET -- 10.4. Radiolabelled Tamoxifen Analogues for Imaging Breast Cancer with SPECT