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TitleMolecular Basis of Human Blood Group Antigens [electronic resource] / edited by Jean-Pierre Cartron, Philippe Rouger
ImprintBoston, MA : Springer US : Imprint: Springer, 1995
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Descript XX, 492 p. 71 illus. online resource


The science of blood groups was born at the beginning of this century, when the field of immunology married that of genetics. Most of the subsequent progress in immunogenetics was achieved by British investigators. The six consecutive editions of the unequaled Blood Groups in Man have long been considered as the bible of blood groupers. It is quite unfortunate that this book has not been revisited since 1975. Although one cannot do without immunogenetics, which remains useful for the identification of new blood groups and genetic studies, the focus of interest has moved somewhat today. After several decades, the molecular basis of blood groups can be investigated by biochemists. From 1950 to 1980, the ABO, Hh, and Lewis blood groups served as models and their chemical basis came to be established. The red cell membrane glycophorins carrying the MN and Ss antigens and the glycolipids with P blood group specificities were also identified and characterized. The chemical basis of the other groups, however, remained largely unknown


1 Red Cell Membrane: Structure and Function -- 2 ABO, Hh, Lewis, and Secretion: Serology, Genetics, and Tissue Distribution -- 3 Biochemistry and Biosynthesis of ABH and Lewis Antigens: Characterization of Blood Group-Specific Glycosyltransferases -- 4 Serology, Biochemistry, and Pathology of Antigens Defined by Cold Agglutinins -- 5 MNSs Blood Groups and Major Glycophorins: Molecular Basis for Allelic Variation -- 6 RH Blood Groups and Rh-Deficiency Syndrome -- 7 Kell Blood Group System and the McLeod Syndrome -- 8 The Duffy Blood Group System and Malaria -- 9 The Kidd Blood Group and Urea Transport -- 10 Lutheran Antigens, Lutheran Regulatory Genes, and Lutheran Regulatory Gene Targets -- 11 P Blood Group and Related Antigens -- 12 Gerbich Blood Groups and Minor Glycophorins -- 13 Sda and Cad Antigens -- 14 Overview of Other Blood Group Systems -- 15 Blood Group Antigens as Markers of Complement and Complement Regulatory Molecules -- 16 Histo-Blood Group Antigens as Tumor-Associated Carbohydrate Antigens and Ligands for Cell Adhesion -- 17 Linkage Relationships and Gene Mapping of Human Blood Group Loc -- 18 Nomenclature of Blood Group Antigens

Medicine Human genetics Immunology Hematology Oncology Biochemistry Medicine & Public Health Oncology Hematology Immunology Biochemistry general Human Genetics


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