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TitleCytokine Knockouts [electronic resource] / edited by Scott K. Durum, Kathrin Muegge
ImprintTotowa, NJ : Humana Press : Imprint: Humana Press, 1998
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Descript XXV, 482 p. online resource


Surveying one of today's most powerful new methodologies, Durum and Muegge assemble in Cytokine Knockouts a unique compendium of the latest information on cytokine knockout mice. Each chapter-written by the leading scientists who created or studied each knockout-illuminates the physiological consequences of deficiency in that cytokine and relates the phenotype to other knockout mice and to human diseases. The effects discussed range from diseases of the bowel, lung, heart, blood, kidney, and liver to immune deficiency, developmental defects, and autoimmunity. Most of the key knockouts of cytokines or receptors, including IL-1 through 8, IFNs, TGFs, TNF, LT, CD40, LIF, CSFs, c-mpl, gp130, and ICE, are thoroughly reviewed. Cytokine Knockouts' many distinguished contributors crystallize their insights into the role of cytokines in health and disease, explain important new concepts in human and animal diseases, and indicate which cytokines should (and should not) become pharmacological targets. Their book offers an authoritative synthesis and review of this important new field and will immediately become a standard resource for today's biomedical researchers


Ch. 1. The IL-2 Deficiency Syndrome: A Lethal Disease Caused by Abnormal Lymphocyte Survival -- Ch. 2. IL-7 Knockout Mice and the Generation of Lymphocytes -- Ch. 3. Lymphoid Development and Function in IL-7R-Deficient Mice -- Ch. 4. CD40 Ligand Knockout Mice -- Ch. 5. Physiological, Immunological, and Pathological Functions of Tumor Necrosis Factor (TNF) Revealed by TNF Receptor-Deficient Mice -- Ch. 6. Cooperation Between the TNF Receptors Demonstrated by TNF Receptor Knockout Mice -- Ch. 7. Immunodeficiency of Tumor Necrosis Factor and Lymphotoxin-? Double-Deficient Mice -- Ch. 8. Characterization of Lymphotoxin-?-Deficient Mice -- Ch. 9. Interleukin-1?-Deficient Mice -- Ch. 10. Functional Phenotype of Mice Deficient in the IL-1R Type 1 Gene: A Comparison with Other Genetically Modified Mice -- Ch. 11. Mice Deficient in Interleukin-1? Converting Enzyme -- Ch. 12. Neutrophilia and B-Cell Plasmacytosis in Mice Lacking the Murine IL-8 Receptor Homolog -- Ch. 13. Knockouts of Interferons, Interferon Receptors and Interferon Signaling Components -- Ch. 14. IL-6 Gene Knockout Mice -- Ch. 15. IL-6 Unique Functions in Inflammation, Bone Metabolism, and B-Cell Neoplasias Revealed by Studies on IL-6 Deficient Mice -- Ch. 16. Myocardial, Hematological, and Placental Disorders Caused by Targeted Disruption of gp130, A Common Signal Transducer for IL-6 Family of Cytokines -- Ch. 17. NF-IL6 Knockout Mice -- Ch. 18. Disruption of the LIF Receptor -- Ch. 19. Phenotypes of TGF? Knockout Mice -- Ch. 20. The Transforming Growth Factor-?1 Knockout Mouse: The Phenotype and Its Implications for TGF?1 Function -- Ch. 21. Granulocyte-Macrophage Colony-Stimulation Factor (GM-CSF)-Deficient Mice -- Ch. 22. The In Vivo Role of the Receptors for IL-3, GM-CSF, and IL-5 (?c and ?IL3) -- Ch. 23. Granulocyte Colony-Stimulating Factor (G-CSF)-Deficient Mice -- Ch. 24. Reduction of Platelets and Megakaryocytes in c-mpl-Deficient Mice

Medicine Immunology Biomedicine Immunology


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