Title | Aging, Carcinogenesis, and Radiation Biology [electronic resource] : The Role of Nucleic Acid Addition Reactions / edited by Kendric C. Smith |
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Imprint | Boston, MA : Springer US : Imprint: Springer, 1976 |
Connect to | http://dx.doi.org/10.1007/978-1-4757-1662-7 |
Descript | XI, 561 p. online resource |
I. Natural Nucleic Acid-Protein Adducts -- Attachment of Chromosomes to Membranes in Bacteria and Animal Cells -- Linkers in Mammalian Chromosomal DNA -- Amino Acids Bound to DNA -- Gene Regulation: Selective Control of DNA Helix Openings -- II. Experimentally-Induced Nucleic Acid Adducts -- Radiation-Induced Cross-Linking of DNA and Protein in Bacteria -- UV-Induced DNA to Protein Cross-Linking in Mammalian Cells -- Role of Protein in the Inactivation of Viruses by Ultraviolet Radiation -- In Vitro Studies of Photochemically Cross-Linked Protein-Nucleic Acid Complexes. Determination of Cross-Linked Regions and Structural Relationships in Specific Complexes -- Photosensitized Cross-Linking of Proteins to Nucleic Acids -- Ionizing Radiation-Induced DNA-Protein Cross-Linking -- Chemically Induced DNA-Protein Cross-Links -- Photochemical Addition of Amino Acids and Related Compounds to Nucleic Acid Constituents -- Addition of Amino Acids and Related Substances to Nucleic Acids by Nucleophilic Catalysis -- Photochemically-Induced Adducts of DNA -- Ionizing Radiation-Induced Attachment Reactions of Nucleic Acids and Their Components -- Repair of DNA Adducts Produced by Alkylation -- Photoaffinity Labeling of Proteins and More Complex Receptors -- III. Relevance of DNA Adducts to Cancer Biology -- Chemically and Metabolically Induced DNA Adducts: Relationship to Chemical Carcinogenesis -- Involvement of Radicals in Chemical Carcinogenesis -- Role of DNA Repair in Mutation and Cancer Production -- IV. Relevance of DNA Adducts to Aging -- Cross-Linkage Hypothesis of Aging: DNA Adducts in Chromatin as a Primary Aging Process -- Dose, Dose Rate, Radiation Quality, and Host Factors for Radiation-Induced Life Shortening -- Protection of Environmentally Stressed Human Cells in Culture with the Free Radical Scavenger, dl-?-Tocopherol -- Role of DNA Repair in Aging