Title | The Use of Human Cells for the Evaluation of Risk from Physical and Chemical Agents [electronic resource] / edited by Amleto Castellani |
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Imprint | Boston, MA : Springer US : Imprint: Springer, 1983 |
Connect to | http://dx.doi.org/10.1007/978-1-4757-1117-2 |
Descript | XI, 809 p. online resource |
Lectures -- What do We Mean by the Expression Risk Assessment? -- The Search for Criteria to Assess the Risks Resulting from Exposure to Carcinogenic Agents -- Some Comments on the Use of Human Cells for Estimates of Risk -- The Strauss-Albertini Test for Direct Enumeration of Drug-Resistant Peripheral Blood Lymphocytes -- Induction of Sister Chromatid Exchange by Chemical Mutagens -- Dose-Response Relation of Chromosome Aberrations -- Mutagen-Induced Chromosome Damage in Man -- Repair of Radiation Damage in Mammalian Cells -- Repair and Expression of Aflatoxin B1-induced DNA Damage -- Parvoviral Probe for Assessing the Mutagenic Risk of Low Doses of Radiation and Chemicals Administered to Human Cells -- Assessment of Human Lymphoid Cell Damage Induced by Therapeutic Levels of 8-Methoxypsoralen and Long Wavelength Ultraviolet Radiation In Vitro -- The Mutagen Sensitivity Response of Cells from Individuals Heterozygous for DNA Repair Deficiency Genes -- Repair of Chemical Damage in Mammalian Cells -- Effects of Various Promoters on Cell Transformation by Simian Virus 40 Mutants -- Repair of Ultraviolet-Light-Induced Damage in Human Skin -- Dosimetry by Means of Measurement of Hemoglobin Alkylation and Risk Estimation Based on the rad-Equivalent Approach -- PUVA Therapy: Immunologic and Genotoxic Approaches to Risk Evaluation -- Parvoviral Probe of DNA Replication in Mammalian Cells Exposed to Genotoxic Agents -- Ultraviolet-Light-Induced Transformation of Human Primary Cells -- Use of Human Lymphoblastoid Cell Lines to Determine Cellular Hypersensitivty to Physical and Chemical Agents -- Cellular Studies on Patients with an Unusual Clinical Sensitivity to Ionizing Radiation -- Electrophilic Reactivity as a Measure of Genotoxic Potency -- SOS Functions Induced in Carcinogen-Treated Mammalian Cells -- Radiation-Induced Transformation in Rodent and Human Cells: Assay Systems and Uses in Risk Estimates -- Correlation of NCI and IARC Carcinogens with Their Mutagenicity in Salmonella -- A Review and Evaluation of Human Genetic Bioassay Data for Some Known or Suspected Human Carcinogens -- From Bacteria to Man, the Evolution of Mutagenicity Testing -- Genetic Bioassay Data on Some Known or Suspected Human Carcinogens -- The Search for Biological Models to Investigate Human Carcinogenic Risks: Human Pathology and Experimental Carcinogenesis Correlations at the Organ, Tissue and Cellular Level, In Vivo and In Vitro -- The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today -- Round Tables -- Reasons for Distrusting Human Risk Assessment Based Solely on In Vitro or Animal Test Results -- Quantitative Relationships, if Any, Between Human and Animal Carcinogenesis: Biological Aspects -- Qualitative and Quantitative Problems in the Extrapolation of Risk to Humans from Animal Data -- Risks from Ambient Chemicals and Radiations -- Human and Other Mammalian Cells: Their Role in Risk Assessment -- Measurements of DNA Repair Activity in Human Cells -- Risk Assessment for Low-Dose and Low-Dose-Rate Radiation -- Difference in Cancer Susceptibility among Individuals and What Determines the Differences -- Calibration and Monitoring of Human Population: Biological Aspects, Hemoglobin Alkylation and Radiation Equivalent Approach -- Communications -- Relaxation of Supercoiled DNA by DNA Modifying Agents: Detection by Gel Electrophoresis -- The MER Phenotype: Human Tumor Cell Strains Defective in Repair of Alkylation Damage -- Growth-Dependent and Age-Related Changes in the Free Amino Acid Pool of Human Diploid Fibroblasts -- DNA Fragmentation and Sister Chromatid Exchanges Induced by Commercial Auramine O, Purified Auramine, and Michlerโs Ketone -- An Attempt to Determine the Origin of DNA Single-Strand Breaks Observed after Treatment of Mammalian Cells with Alkylating Agents -- Localization of Genes Involved in DNA Repair on Human Chromosomes by Using Cell Fusion -- In Vitro Studies on Chemical Carcinogenesis in Balb/c 3T3 Cells -- The Chemical Hazard of Anto-Implantation Assessed and Analyzed Both In Vitro and In Vivo -- Cellular Specificity in DNA Damage, Repair, and Replication during Chronic Carcinogen Exposure -- The Problem of Specificity in the Assessment of Risk from Chemicals and Radiation-Breast Cancer Models -- Author index