Title | Molecular Biology of Brain and Endocrine Peptidergic Systems [electronic resource] / edited by Michel Chrรฉtien, Kenneth W. McKerns |
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Imprint | Boston, MA : Springer US : Imprint: Springer, 1988 |
Connect to | http://dx.doi.org/10.1007/978-1-4684-8801-2 |
Descript | XI, 321 p. online resource |
Genetic Engineering of Polypeptide Hormones (Mutagenesis) -- Functional Dissection of a cAMP-Response Element Using Recombinant Mutations -- Structure Activity Relationship and Peptide Drug Design -- Conformational Constraints in the Design of Receptor Selective Peptides: Conformational Analysis and Molecular Dynamics -- Angiotensin II Antagonists with Prolonged Duration of Action, Possible Anti-Hypertensive Drugs -- New Concepts in Peptide Analog Design -- Clinical and Experimental Applications of Polypeptide Hormones -- Neuropeptidergic Pathways as Possible Targets for the Development of New Therapeutic Agents -- Combination Therapy with the Antiandrogen Flutamide and the LHRH Agonist [D-Trp6, des-Gly-NH210]LHRH Ethylamide in Prostate Cancer: Rationale and 5-year Clinical Experience -- Organelle Organization and Intracellular Trafficking -- Proinsulin Conversion Site -- Hormone and Receptor Ligand Interactions -- Regulation of the Adenylate Cyclase Signalling Pathway: Potential Role for the Phosphorylation of the Catalytic Unit by Protein Kinase A and Protein Kinase C -- Role of Glycosylation in Ligand-Receptor Interactions and Signal Transduction Mechanisms -- Post-Translational Processing of Peptide Hormones -- Molecular Structure of Neutral Endopeptidase 24.11 (Enkephalinase) -- The Possible Role of Plasma Kallikrein in Pro-Hormone and Pro-Enzyme Processing -- Sequence Analysis of the Carboxypeptidase E Precursor -- Cellular Mechanisms of Peptide Processing: Focus on ?-Amidation -- The Yeast KEX1 Gene Product Acts as a Carboxypeptidase B-Like Protease in Processing Secreted Protein Precursors -- Receptor Localization and in Situ Hybridization -- Regulation of mRNA in Peptidergic Systems: Quantitative and In Situ Studies -- Cellular and Sub-Cellular Localization of Brain Neurotensin Receptors -- Gonadotropins and Novel Gonadal Peptides. Isolation, Structure and Cloning -- Diversity of Novel Proteins of Gonadal Fluids -- Biochemical and Biological Characterization of LH and FSH Expressed by Recombinant DNA Technology -- Regulation of Neuropeptide Gene Expression -- DNA Binding Proteins and Their Roles in Controlling Tissue Specific Gene Expression and the Responses to Second Messengers -- Molecular Biology and Physiology of Aplysia Neuropeptides