Title | Cytotoxic Cells: Recognition, Effector Function, Generation, and Methods [electronic resource] / edited by Michail V. Sitkovsky, Pierre A. Henkart |
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Imprint | Boston, MA : Birkhรคuser Boston, 1993 |
Connect to | http://dx.doi.org/10.1007/978-1-4684-6814-4 |
Descript | XIV, 528 p. online resource |
Section I: Introduction and Overview -- I Introductory Remarks -- 2 T-Cell-Mediated Cytotoxicity: A Historical Note -- 3 Overview of CTL-Target Adhesion and Other Critical Events in the Cytotoxic Mechanism -- Section II: Target Cell Recognition -- 4 ?? T-Cell Receptor Repertoires Among Cytotoxic and Helper T Lymphocytes -- 5 Class I MHC/Peptide/?2-Microglobulin Interactions: The Basis of Cytotoxic T-Cell Recognition -- 6 The Role of CD8-Class I Interactions in CTL Function -- 7 Interactions Between CD2 and T-Cell Receptor Isoforms in CTL Function -- 8 Triggering Structures on NK Cells -- 9 Targeted Cellular Cytotoxicity -- Section III: Generation of Cytotoxic Cells -- 10 Immunobiology and Molecular Characteristics of Peritoneal Exudate Cytotoxic T Lymphocytes (PEL), Their In Vivo IL-2 Dependent Blasts and IL-2 Independent Cytolytic Hybridomas -- 11 Regulatory Effects of Cytokines on the Generation of CTL and LAK Cells -- 12 IL-2-Independent Activation of LAK Cells by a Heterodimeric Cytokine, Interleukin-12 -- 13 Immunobiology of ?2-Microglobulin-Deficient Mice -- Section IV: Molecular Mechanisms of Cellular Cytotoxicity -- 14 The Granule Exocytosis Model for Lymphocyte Cytotoxicity and Its Relevance to Target Cell DNA Breakdown -- 15 Subpopulations of Cytotoxic T Lymphocytes with Different Cytotoxic Mechanisms -- 16 Multiple Lytic Pathways in Cytototoxic T Lymphocytes -- 17 Properties of Cytotoxicity Mediated by CD4+, Perforin-Negative T-Lymphocyte Clones -- 18 Direct Contact of Cytotoxic T Lymphocyte Receptors with Target Cell Membrane Determinants Induces a Prelytic Rise of [Ca2+]1 in the Target That Triggers Disintegration -- 19 Target Cell Events Initiated by T-Cell Attack -- 20 Apoptosis and Cytotoxic T Lymphocytes -- 21 Molecular Mechanisms of Lymphocyte Cytotoxicity -- Section V: Granule Proteases -- 22 Subtractive and Differential Molecular Biology Approaches to Molecules Preferentially Expressed in Cytotoxic and Other T Cells -- 23 Structure and Possible Functions of Lymphocyte Granzymes -- 24 The Role of Granzyme A in Cytotoxic Lymphocyte-Mediated Lysis -- 25 The Granzyme A Gene: A Marker for Cytolytic Lymphocytes In Vivo -- 26 Molecular Analysis and Possible Pleiotropic Function(s) of the T Cell-Specific Serine Proteinase-1 (TSP-1) -- 27 Serine Protease Control of Lymphocyte-Mediated Cytolysis -- Section VI: Alternative Mechanisms of Cytolysis -- 28 Possible Role of Extracellular ATP in Cell-Cell Interactions Leading to CTL-Mediated Cytotoxicity -- 29 Cell-Permeabilizing Properties of Extracellular ATP in Relation to Lymphocyte-Mediated Cytotoxicity -- 30 The Role of Free Fatty Acids in CTL-Target Cell Interactions -- Section VII: Biochemical and Immunopharmacological Manipulations of Cytotoxic Cells -- 31 Identification of Protein Kinases and Protein Phosphatases Involved in CTL Effector Functions. โONโ and โOFFโ Signaling and Immunopharmacological Implications -- 32 Cytolytic Granules as Targets for Immunosuppressive Therapy: Selective Ablation of CTL by Leucyl-Leucine Methyl Ester -- Section VIII: Functions of Cytotoxic Cells in Vivo -- 33 Role of CD8+?? T Cells in Respiratory Infections Caused by Sendai Virus and Influenza Virus -- 34 CD4+ and CD8+ Cytolytic T Lymphocyte Recognition of Viral Antigens -- 35 Can CTL Control Virus Infections Without Cytolysis? The Prelytic Halt Hypothesis -- 36 Immunologic Control of Toxoplasma Gondii Infection by CD8+ Lymphocytes: A Model for Class I MHC- Restricted Recognition of Intracellular Parasites -- 37 Antigen-Specific Suppression of Antibody Responses by Class II MHC-Restricted CTL -- 38 The Immunosenescence of Cytolytic T Lymphocytes (CTL): Reduction of Pore-Forming Protein and Granzymc Levels -- 39 Bone Marrow Graft Rejection as a Function of TNK Cells -- 40 Class I MHC Antigens and the Control of Virus Infections by NK Cells -- 41 Clinical Trials of Immunotherapy of Cancer Utilizing Cytotoxic Cells -- Section IX: Macrophage-Mediated Cytotoxicity -- 42 Macrophage-Mediated Cytotoxicity -- Section X: Methods -- 43 The 51Cr-Release Assay for CTL-Mediated Target Cell Lysis -- 44 DNA Fragmentation and Cytolysis Assayed by 3H-Thymidine -- 45 The JAM Test: An Assay of Cell Death -- 46 Target Cell Detachment Assay -- 47 Protocol for Assaying CTL Activity Against Toxoplasma gondii -- 48 Granule Exocytosis Assay of CTL Activation -- 49 Measurement of Cytolysin Hemolytic Activity -- 50 SPDP Crosslinking of Antibodies to Form Heteroconjugates Mediating Redirected Cytotoxicity -- 51 Derivatization of Cells with Antibody -- 52 Mixed Lymphocyte Culture for the Generation of Allospecific CTL -- 53 Generation of CD4+ and CD8+ Antiinfluenza CTL and Assay of In Vitro Cytotoxicity -- 54 Generation of Antigen-Specific M urine CTL Under Weakly Immunogenic Conditions -- 55 Commercial Liposomes and Electroporation Can Deliver Soluble Antigen for Class I Presentation in CTL Generation -- 56 Stimulation of CTLs on Antibody-Coated Plates -- 57 CTL Recognition of Purified MHC Antigens and Other Cell Surface Ligands -- 58 Use of Protease Inhibitors as Probes for Biological Functions: Conditions, Controls, and Caveats -- 59 The Murine T Cell-Specific Serine Proteinase-1: Cleavage Activity on Synthetic and Natural Substrates -- 60 Detection of Specific mRNAs by In Situ Hybridization