Title | Novel Approaches to the Treatment of Alzheimer's Disease [electronic resource] / edited by Edwin M. Meyer, James W. Simpkins, Jyunji Yamamoto |
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Imprint | Boston, MA : Springer US, 1989 |
Connect to | http://dx.doi.org/10.1007/978-1-4684-5727-8 |
Descript | XIV, 386 p. 137 illus. online resource |
Section I. Drugs that Act at Cholinergic Receptors -- A Functionalized Congener Approach to Muscarinic Ligands -- AF102B: A Novel M1 Agonist as a Rational Treatment Strategy in Alzheimer's Disease -- Muscarinic Receptors, Phosphoinositide Hydrolysis and Neuronal Plasticity in the Hippocampus -- Effects of Cholinergic Drugs on Extracellular Levels of Acetylcholine and Choline in Rat Cortex, Hippocampus and Striatum Studied byu Brain Dialysis -- Delayed Matching-to-Sample in Monkeys as a Model for Learning and Memory Deficits: Role of Brain Nicotinic Receptors -- Muscarinic and Nicotinic Receptors in Alzheimer's Disease: Rationale for Cholinergic Drug Treatment -- Section II. CNS-Active Neurotrophic Factors -- Potential Pharmacological Use of Neurotrophic Factors in the Treatment of Neurodegenerative Diseases -- The Use of Reaggregating Cell Cultures and Immortalized Central Nervous System Cells to Study Cholinergic Trophic Mechanisms -- Approaches to Gene Therapy in the CNS: Intracerebral Grafting of Fibroblasts Genetically Modified to Secrete Nerve Growth Factor -- Exogenous Nerve Growth Factor Stimulates Choline Acetyltransferase Activity in Basal Forebrain of Axotomized and Aged Rats -- Neuronotrophic Factors, Gangliosides and Their Interaction: Implications in the Regulation of Nervous System Plasticity -- Suppression of Active Neuronal Death by Immune Interferon -- Basic Fibroblast Growth Factor, an Example of a Multifunctional Trophic Factor with Neurotrophic Activity -- Growth Factor and Lymphokine Effects on Brain Cholinergic Systems -- Metabolic Support of Neural Plasticity: Implications for the Treatment of Alzheimers Disease -- Section III. Additional Novel Treatment Strategies: Improved Brain Delivery, Hormones, and Immunology -- Brain-Enhanced Delivery of Anti-Dementia Drugs -- Development of a Pyrrolidinone Derivative (Cyclic GABA)for Modulating Brain Glutamate Transmission -- A Brain-Enhanced Chemical Delivery System for Gonadal Steroids: Implications for Neurodegenerative Diseases -- Immunologic Approach to Therapy in Alzheimer's Disease -- The Influence of ACTH 4โ9 Analog upon Avoidance Learning in Normal and Brain Damaged Rats -- Section IV. Models for Drug-Development: Cholinergic Hypofunction -- Transneuronal Neurochemical and Neuropathological Changes Induced by Nucleus Basalis Lesions: A Possible Degenerative Mechanism in Alzheimer's Disease -- Presynaptic Markers of Cholinergic Function in Cortex Following Ibotenic Acid Lesion of the Basal Forebrain -- Cholinergic-Neuropeptide Y Interactions in the Rat Cerebralcortex: Towards a Model for the Trans-synapticEffects of Cholinergic Transmission -- The Effects of Nucleus Basalis Lesions in the Rat on One Way Passive and Active Avoidance, Two Way Avoidance and Lashly III Maze Learning: An Animal Model for SDAT -- Section V. Models for Drug Development: Other Neurochemical and Behavioral Changes -- NMDA Receptors, Aging and Alzheimer's Disease -- An Excitotoxic Model of Alzheimer's Disease: NMDA Lesions and Initial Neural Grafting Results -- Excitotoxin Mediated Neuronal Loss and the Regulation of Excitatory Amino Acid Release in the Aging Brain -- EEG Power Spectra and Brain Function -- Postmortem Stability of RNA Metabolism in Human Brain: Studies of the Nondemented Conrol and Alzheimer's Disease Cases -- A Model System Demonstrating Parallels in Animal and Human Aging: Extension to Alzheimer's Disease -- Computer-Simulated Everyday Memory Testing for Clinical Trials in Memory Disorders of Aging