This book is directed primarily to advanced graduate and medical students, postdoctoral trainees, and established investigators having basic research interests in neoplasia. Its content is based in part on the lecture outlines and selected histopathology laboratory components of an advanced course entitled The Pathobiology of Experimental Animal and Human Neoplasia, developed by me for the Experimental Pathology Curriculum of the Department of Pathology at the Medical College of Virginia. In this regard, an effort has been made to integrate pathology with carcinogenesis, genetics, biochemistry, and cellular and molecular biology in order to present a comprehensive and current view of the neoplastic process. For focus, emphasis is mainly being placed on the neoplastic cells themselves, and not on associated host-mediated responses. It ishoped that this book will accomplish its purpose of providing students and researchers who already possess strong but diverse basic science backgrounds with unifying concepts in tumor pathobiology, so as to stimulate new research aimed at furthering our understanding of neoplastic disease. I wish to express my appreciation and heartfelt thanks to the authors, whose individual ranges of expertise and research experience clearly bring to their respective chapters unique perspectives that easily transcend any redundancy that may be present. In addition, I am grateful to Drs. George Vennart, Saul Kay, and Fred Meier, and to Ms. Connie Wilkerson of the Department of Pathology at MCV, for their helpful comments and their review of some of the material
CONTENT
Introduction: Chronology of Significant Events in the Study of Neoplasia -- 1. Classification of Neoplasms -- 2. Chemical Carcinogenesis in Experimental Animals and Humans -- 3. DNA Adducts and Carcinogenesis -- 4. Oncogenic Viruses -- 5. Radiation Carcinogenesis -- 6. The Multistage Concept of Carcinogenesis -- 7. Organ and Species Specificity in Chemical Carcinogenesis and Tumor Promotion -- 8. DNA Repair Mechanisms and Carcinogenesis -- 9. Preneoplasia and Precancerous Lesions -- 10. Tumor Progression and the Clonal Evolution of Neoplasia -- 11. Cytogenetics and Human Neoplasia -- 12. Genetics of Susceptibility to Mouse Skin Tumor Promotion -- 13. Oncogenes -- 14. Activation of Oncogenes by Chemical Carcinogens -- 15. Alterations in Biochemical Control Mechanisms of Neoplastic Cells -- 16. Membrane Alterations in Neoplasia -- 17. Growth Factors and Neoplasia -- 18. Biochemical Mechanisms of Action of the Phorbol Ester Class of Tumor Promoters -- 19. Biochemical Marker Alterations in Hepatic Preneoplasia Neoplasia -- 20. Oncogene Activation and Expression during Carcinogenesis in Liver and Pancreas -- 21. Oncodevelopmental Expression and Neoplasia -- 22. Expression of Differentiated Function in Neoplasms -- 23. Ectopic Hormone Production and Neoplasia -- 24. Metaplastic Transformation of Pancreatic Cells to Hepatocytes -- 25. Crown Gall Neoplasms -- 26. Angiogenesis: Factors and Mechanisms -- 27 Tumor Invasion and Metastases: Biochemical Mechanisms -- 28. Phenotypic Heterogeneity and Metastasis
