Title | Somatostatin [electronic resource] : Basic and Clinical Status / edited by Seymour Reichlin |
---|---|
Imprint | Boston, MA : Springer US : Imprint: Springer, 1987 |
Connect to | http://dx.doi.org/10.1007/978-1-4684-5326-3 |
Descript | XI, 373 p. online resource |
I. Biosynthesis and Processing -- 1. Regulation and Diversity of Peptide Hormone Gene Expression -- 2. Structure and Regulation of the Rat Somatostatin Gene -- 3. Regulation of Somatostatin Gene Expression by Cyclic AMP -- 4. Peptides Derived from Mammalian Prosomatostatin -- 5. Expression of Preprosomatostatin in Foreign Cells: Secretion of Mature Somatostatin by Yeast (Saccharomyces Cerevisiae) -- 6. Cotranslational and Posttranslational Proteolytic Processing of Preprosomatostatin-I and Preprosomatostatin-II in Intact Islet Tissue -- 7. Environmental Regulation of Neurotransmitter Phenotypic Expression in Sympathetic Neurons -- II. Mechanisms of Action -- 8. Side Chain Conformations of Somatostatin Analogs When Bound to Receptors -- 9. Somatostatin Receptor: Evidence for Functional and Structural Heterogeneity -- 10. Structural Analysis of Somatostatin Receptors -- 11. Mode of Action of Somatostatin in Islet B-Cells: Influence on Glucose-, L-isoleucine- and Glyburide-Induced Electrical Activity -- 12. Mechanisms by Which Somatostatin Inhibits Pituitary Hormone Release -- 13. Molecular Mechanisms of Somatostatin Inhibition of. Hormone Release From AtT-20 Cells -- III. Role of Somatostatin in Nervous System Function and Controversies in Somatostatin Research -- 14. Regulation of Hypothalamic Somatostatin Secretion -- 15. Somatostatin and Behavior: Preclinical and Clinical Studies -- 16. Physiological Significance of Somatostatin in Growth Hormone Regulation -- 17. Somatostatin and Depression -- 18. Cytoprotection by Somatostatins -- 19. Evidence for Paracrine Function of Somatostatin -- 20. Evidence for the Endocrine Role of Somatostatin -- IV. Somatostatin in Gastrointestinal Function -- 21. Gut Somatostatin -- 22. Regulation of Somatostatin Release From Dispersed Canine Fundic D-Cells -- 23. Antral Somatostatin: A Paracrine Regulator of Gastrin Secretion -- 24. Somatostatin Inhibits Intestinal Motility Via Modulation of Cyclic Amp-Dependent Cholinergic Transmission . -- 25. Multiple Mechanisms Appear to Underlie the Antisecretory Action of Somatostatin on Acid Secretion -- 26. Somatostatin in Gastrointestinal Function: Intestinal Absorption and Secretion -- 27. Effect of Somatostatin on Exocrine Pancreas -- 28. Somatostatin, Clearance and Inhibition of Gastric Acid Secretion in Duodenal Ulcer Patients -- V. Clinical Applications -- 29. Effect of a Long-Acting Somatostatin Analog (SMS 201โ995) on Glucose Homeostasis in Type I Diabetes and in Acromegaly -- 30. Treatment of Diabetes with L363,586 -- 31. Somatostatin and Upper Gastrointestinal Hemorrhage -- 32. Somatostatin and Analogs in the Management of Variceal Hemorrhage -- 33. Somatostatin in the Treatment of Hematemesis and Melena -- 34. Somatostatin Octapeptide in the Medical Treatment of Acromegaly -- 35. Efficacy and Safety of a Somatostatin Analogue in Active Acromegaly -- 36. Treatment of Gut-Associated Neuroendocrine Tumors with the Long-Acting Somatostatin Analog, SMS 201โ995 -- 37. Somatostatin in the Treatment of Acute Pancreatitis -- Author Index