Office of Academic Resources
Chulalongkorn University
Chulalongkorn University

Home / Help

TitleRegulation of Hepatic Metabolism [electronic resource] : Intra- and Intercellular Compartmentation / edited by Ronald G. Thurman, Frederick C. Kauffman, Kurt Jungermann
ImprintBoston, MA : Springer US, 1986
Connect tohttp://dx.doi.org/10.1007/978-1-4684-5041-5
Descript 510 p. online resource

SUMMARY

The liver is an exceptionally complex and diverse organ that functions both as an exocrine and an endocrine gland. It secretes bile, which contains many conยญ stituents in addition to bile salts, and it synthesizes and releases many substances in response to the body's demands, including prohormones, albumin, clotting factors, glucose, fatty acids, and various lipoproteins. It has a dual blood supply providing a rich mixture of nutrients and other absorbed substances via the portal vein and oxygen-rich blood via the hepatic artery. This functional heterogeneity is accompanied by cellular heterogeneity. The liver contains many cell types including hepatic parachymal cells, Kiipffer cells, Ito cells, and endothelial cells. The most abundant cell type, the parenchymal cells, are biochemically and structurally heterogeneous. The cells in the oxygen-rich areas of the portal triad appear more dependent on oxidative metabolism, whereas those around the central vein (pericentral, perivenous, or centrolobular areas) are more dependent upon an anaerobic mechanism. Throughout this volume the latter three terms are used synonymously by various authors to indicate the five to eight layers of cells radiating from the central vein. Structural and metabolic heterogeneity of hepatic parenchymal cells has been demonstrated by a variety of approaches, including histochemical, ultraยญ structural, and ultramicrobiochemical studies. This microheterogeneity is linked to the physiological functions of the liver and its response to injurious substances


CONTENT

I. Liver Structure -- 1 Liver Structure and Innervation -- 2 Hepatic Hemodynamics and Microcirculation -- II. Methods -- 3 Histology and Histochemistry -- 4 Immunohistochemistry -- 5 Quantitative Histochemical Measurements within Sublobular Zones of the Liver Lobule -- 6 Separation of Functionally Different Liver Cell Types -- 7 New Micromethods for Studying Sublobular Structure and Function in the Isolated, Perfused Rat Liver -- 8 Redox Scanning in the Study of Metabolic Zonation of Liver -- III. Distribution of Metabolic Functions -- 9 Metabolism of Carbohydrates -- 10 Metabolism of Lipids -- 11 Metabolism of Amino Acids and Ammonia -- 12 Lobular Oxygen Gradients: Possible Role in Alcohol-Induced Hepatotoxicity -- 13 Biotransformation and Zonal Toxicity -- 14 Protein Synthesis and Secretion -- 15 Bile Acid Metabolism -- IV. Induction of Liver Cell Heterogeneity -- 16 Zonal Signal Heterogeneity and Induction of Hepatocyte Heterogeneity -- V. Speculations and Directions for the Future -- Challenges for the Future


Medicine Pharmacology Gastroenterology Hepatology Medicine & Public Health Gastroenterology Hepatology Pharmacology/Toxicology



Location



Office of Academic Resources, Chulalongkorn University, Phayathai Rd. Pathumwan Bangkok 10330 Thailand

Contact Us

Tel. 0-2218-2929,
0-2218-2927 (Library Service)
0-2218-2903 (Administrative Division)
Fax. 0-2215-3617, 0-2218-2907

Social Network

  line

facebook   instragram