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AuthorThomas, John A. author
TitlePrinciples of Endocrine Pharmacology [electronic resource] / by John A. Thomas, Edward J. Keenan
ImprintBoston, MA : Springer US, 1986
Connect tohttp://dx.doi.org/10.1007/978-1-4684-5036-1
Descript 310 p. online resource

SUMMARY

The authors have provided an overview of the relationships between hormones that are physiologic constituents of the body as well as their pharmacologic use in replacement therapies and related endocrine dysยญ function. Principles of Endocrine Pharmacology concerns itself with the therยญ apeutic use of hormones, and hormone like substances, or drugs that can act either by suppressing or enhancing the metabolism of certain glands of internal secretion. Other drugs used for nonendocrine therยญ apies can likewise affect the endocrine system. Endocrine pharmacology emerged in the early 1900s with the use of crude pituitary extracts. By the mid-1900s several investigators had isolated and begun to synthesize hormones or hormonelike substances. Recognizing the limited supply of hormones that could be obtained both from animal sources and human autopsy material, the search for soยญ called hormone substitutes also began early in the 1900s. Recently, reยญ combinant DNA technologies have been used to provide alternative therapeutic sources of human insulin and human growth hormone. Aside from insulin, perhaps no other use of hormonally-active subยญ stance is better exemplified by those drugs which affect fertility. The synthesis of an orally-effective steroid represented one of the first major breakthroughs in the chemical suppression of ovulation. Since the orallyยญ active 19-norsteroids were introduced in the 1950s, several oral contraยญ ceptive steroid preparations have been marketed. Indeed, the advent of oral contraceptives for birth control has led to a renewed interest in endocrine pharmacology


CONTENT

1. Introduction and General Mechanisms of Hormonal Actions -- 1.1. History and Scope of Endocrine Pharmacology -- 1.2. General Concepts of Hormone Actions -- 1.3. Hormonal Feedback Systems -- Recommended Readings -- 2. Pharmacology of Adenohypophyseal Hormones -- 2.1. Factors Modifying Adenohypophyseal Secretion: Hypophysiotrophic Hormones -- 2.2. Pharmacology of Anterior Pituitary Hormones -- Recommended Readings -- 3. Posterior Pituitary Hormones, Oxytocics, and Prostaglandins -- 3.1. Posterior Pituitary Hormones -- 3.2. Ergot Alkaloids -- 3.3. Prostaglandins: Reproductive Actions -- Recommended Readings -- 4. Thyroid and Antithyroidal Drugs -- 4.1. Thyroid -- 4.2. Antithyroidal Agents -- 4.3. Drug Interactions and Thyroid Function Tests -- Recommended Readings -- 5. Parathyroid Hormone and Calcitonin -- 5.1. Introduction -- 5.2. History -- 5.3. Parathyroid Hormone -- 5.4. Calcitonin -- Recommended Readings -- 6. Androgenic and Anabolic Steroids -- 6.1. Introduction -- 6.2. History -- 6.3. Chemistry -- 6.4. Biosynthesis, Secretion, and Metabolism -- 6.5. Mechanism of Action -- 6.6. Physiological and Pharmacological Actions of Androgens -- 6.7. Preparations -- 6.8. Therapeutic Uses -- 6.9. Adverse Effects -- 6.10. Weak or Impeded Androgens -- 6.11. Androgen Antagonists -- Recommended Readings -- 7. Estrogens and Antiestrogenic Drugs -- 7.1. Estrogens -- 7.2. Antiestrogens -- Recommended Readings -- 8. Progestins and Oral Contraceptives -- 8.1. Progestins -- 8.2. Oral Contraceptives -- Recommended Readings -- 9. Adrenocorticosteroid Drugs -- 9.1. Introduction -- 9.2. History -- 9.3. Chemistry -- 9.4. Biosynthesis, Secretion, and Metabolism -- 9.5. Mechanism of Action -- 9.6. Physiological and Pharmacological Actions -- 9.7. Preparations -- 9.8. Therapeutic Uses -- 9.9. Adverse Effects -- 9.10. Inhibitors of Adrenocortical Steroid Biosynthesis -- Recommended Readings -- 10. Insulin and Oral Hypoglycemic Agents -- 10.1. Insulin -- 10.2. Oral Hypoglycemic Agents -- 10.3. Glucagon -- 10.4. Somatostatin -- 10.5. Nonhormonal Hyperglycemic Agents -- Recommended Readings -- 11. Effects of Drugs on the Endocrine System -- 11.1. Introduction -- 11.2. Basic Mechanisms of Drug-Hormone Interactions -- 11.3. Effects of Drugs on Adenohypophyseal Function -- 11.4. Effects of Drugs on Neurohypophyseal Function -- 11.5. Effects of Drugs on Lactation and Their Presence in Milk -- 11.6. Effects of Drugs on Hormone Transport -- 11.7. Effects of Drugs on Steroidogenesis -- 11.8. Effects of Drugs on Gonadal Function -- 11.9. Effects of Drugs on Pancreatic Function -- 11.10. Effects of Drugs on Thyroid Function -- 11.11. Effects of Drugs on Laboratory Analyses -- Recommended Readings


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