Title | Genotoxicology of N-Nitroso Compounds [electronic resource] / edited by T. K. Rao, W. Lijinsky, J. L. Epler |
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Imprint | Boston, MA : Springer US, 1984 |
Connect to | http://dx.doi.org/10.1007/978-1-4684-4595-4 |
Descript | XVI, 271 p. 24 illus. online resource |
1. Formation of N-Nitroso Compounds and Their Significance -- 2. N-Nitrosamine Mutagenicity Using the Salmonella/Mammalian-Microsome Mutagenicity Assay -- 1. Introduction -- 2. Materials and Methods -- 3. Mutagenic Activity and Chemical Structure -- 4. Conclusions / Discussion -- 5. References -- 3. Structural Basis for Mutagenic Activity of N-Nitrosamines in the Salmonella Histidine Reversion Assay -- 1. Introduction -- 2. Salmonella typhimuriumโHistidine Reversion Assay -- 3. Mutagenesis Studies in Salmonella typhimurium -- 4. References -- 4. Effects of pH and Structure on the Mutagenic Activity of N-Nitroso Compounds -- 1. Introduction -- 2. Methods -- 3. Effects of pH on Mutagenesis and DNA Alkylation by N-Nitroso Compounds -- 4. Mutagenesis by N-Nitroso-Nโ-nitroso-N-alkylguanidines -- 5. Repair of O6-Methylguanine and Its Effect on Mutagenesis -- 6. Alternate Mechanisms of Mutagenesis by N-Nitroso Compounds -- 7. Mutagenesis by a Series of โWeakly Mutagenicโ N-Nitrosamines: Effects of Structure -- 8. Correlation between Mutagenic Potencies and Carcinogenic Activities of Some N-Nitroso Compounds -- 9. References -- 5. Induction of Bacteriophage Lambda by N-Nitroso Compounds -- 1. Mechanism of Induction -- 2. Genetics and Methodology -- 3. Factors Affecting Induction by Nitroso Compounds -- 4. Structure-Activity Relationships -- 5. Relationships between Mutagenicity, Carcinogenicity, and Phage Induction -- 6. Mechanism of Action of Nitroso Compounds as Inducers of Bacteriophage Lambda -- 7. References -- 6. The Relationship between the Carcinogenicity and Mutagenicity of Nitrosamines in a Hepatocyte-Mediated Mutagenicity Assay -- 7. Mutagenic Activity of Nitrosamines in Mammalian Cells: Study with the CHO/HGPRT and Human Leukocyte SCE Assays -- 1. Introduction -- 2. Mutagenic Activity of Eight Nitrosamines in the CHO / HGPRT Assay -- 3. Mutagenic Activity of 15 Nitrosamines in the Human Leukocyte SCE Assay -- 4. Summary and Concluding Remarks -- 5. References -- 8. Dimethylnitrosamine Demethylase and the Mutagenicity of Dimethylnitrosamine: Effects of Rodent Liver Fractions and Dimethylsulfoxide -- 1. Introduction -- 2. Materials and Methods -- 3. Results -- 4. Discussion -- 5. References -- 9. The Relationship between Metabolism and Mutagenicity of Two Cyclic Nitrosamines -- 1. Introduction -- 2. Materials and Methods -- 3. Results and Discussion -- 4. Conclusion -- 5. References -- 10. StructureโActivity Relations in Carcinogenesis by N-Nitroso Compounds -- 1. Introduction -- 2. Nitrosoalkylamides -- 3. Alkylation by Nitrosamines -- 4. Nitrosomethylalkylamines (X) -- 5. Substituted Acyclic Nitrosamines -- 6. Cyclic Nitrosamines -- 7. Substituted Cyclic Nitrosamines -- 8. Derivatives of Nitrosopiperidine -- 9. Conclusion -- 10. References -- 11. Comparison of Mutagenic and Carcinogenic Properties: A Critique -- 1. Introduction -- 2. Tabular Summation and Integration of Results -- 3. Comparison of Mutagenic End Points -- 4. Relationship between Short-Term Test Results and Carcinogenicity -- 5. Precautions in Interpretation and Extrapolation -- 6. References