Title | The Year in Metabolism 1977 [electronic resource] / edited by Norbert Freinkel |
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Imprint | Boston, MA : Springer US, 1978 |
Connect to | http://dx.doi.org/10.1007/978-1-4684-2499-7 |
Descript | XX, 448 p. 5 illus. online resource |
1 Cyclic GMP in Metabolism: Interrelationships of Biogenic Amines, Hormones, and Other Agents -- 1.1. Introduction -- 1.2. Formation and Degradation of Cyclic GMP -- 1.3. Regulation of Cyclic GMP in Tissues -- 1.4. Some Physiologic Effects That May Correlate with Cyclic GMP -- 1.5. Clinical Studies with Cyclic Nucleotides -- References -- 2 Diabetes Mellitus -- 2.1. Heterogeneity of Diabetes Mellitus -- 2.2. Relationship of Fuels to Hormonal Release and Fuel Economy -- 2.3. Glucagon SecretionโSomatostatin -- 2.4. Epidemiological Findings -- 2.5. Control of Diabetes -- 2.6. Long-Term Complications -- 2.7. Diabetes in Pregnancy -- 2.8. Treatment of Diabetes Mellitus -- References -- 3 Glucagon and Somatostatin -- 3.1. Immunoreactive Glucagons in Tissues and Plasma -- 3.2. Structure-Function Relationships of Glucagon -- 3.3. Molecular Basis for Glucagon Actions -- 3.4. Glucagon Metabolism, Clearance, and Degradation -- 3.5. Physiologic Actions of Glucagon -- 3.6. Physiologic Roles of Glucagon in Fuel Homeostasis -- 3.7. Concept of the Bihormonal Unit -- 3.8. Control of Glucagon Secretion -- 3.9. Extrapancreatic Glucagon -- 3.10. Somatostatin -- 3.11. Morphofunctional Interrelationships of the Endocrine Pancreas: Microanatomic Organization of the Islets of Langerhans -- 3.12. Importance of Glucagon in Clinical MedicineโDiabetes Mellitus -- References -- 4 Body Fuel Metabolism -- 4.1. Introduction -- 4.2. Glucose Metabolism -- 4.3. Amino Acid Metabolism -- 4.4. Ketone and Fatty Acid Metabolism -- 4.5. Fuel Metabolism in Exercise -- References -- 5 Whatโs New in the Treatment of Obesity? -- 5.1. Introduction -- 5.2. The Core Problem of Treatment -- 5.3. Hypothetical Defended Variables in Obesity -- 5.4. Implications for Treatment -- 5.5. Current New Approaches in Treatment -- 5.6. Conclusion -- References -- 6 Disorders of Lipid and Lipoprotein Metabolism -- 6.1. Introduction -- 6.2. Lipoprotein Structure and Metabolism -- 6.3. Hyperlipidemias -- 6.4. High-Density-Lipoprotein Levels and Coronary Heart Disease -- 6.5. Type III Hyperlipoproteinemia -- 6.6. Cholesterol Metabolism and Its Regulation -- 6.7. Familial Hypercholesterolemia -- 6.8. ?-Sitosterolemia and Cerebrotendinous Xanthomatosis -- 6.9. Hypertriglyceridemia -- 6.10. Chronic Renal Failure and Hyperlipidemia -- 6.11. Treatment of Hyperlipidemia -- References -- 7 Metabolism of Amino Acids and Organic Acids -- 7.1. Introduction -- 7.2. Phenylketonuria and Its Variants -- 7.3. The ?-Glutamyl Cycle and 5-Oxoprolinuria -- 7.4. Jamaican Vomiting Sickness and Glutaric Aciduria Type II: Similar Organic Acidurias with Different Etiologies -- References -- 8 Disorders of Purine and Pyrimidine Metabolism -- 8.1. Introduction -- 8.2. Purine Metabolism -- 8.3. Adenosine Deaminase (ADA) Deficiency Associated with Severe Combined Immunodeficiency Disease -- 8.4. Increased Activity of ADA in Red Cells Associated with Hereditary Hemolytic Anemia -- 8.5. Purine Nucleoside Phosphorylase (PNP) Deficiency -- 8.6. Purine 5?-Nucleotidase Deficiency in Primary Hypogammaglobulinemia -- 8.7. Hereditary Xanthinuria -- 8.8. Hypoxanthine-Guanine Phosphoribosyl transferase (HPRT) Deficiency -- 8.9. Increased Activity of Phosphoribosylpyrophosphate Synthetase -- 8.10. Adenine Phosphoribosyltransferase (APRT) Deficiency -- 8.11. Nucleoside Triphosphate Pyrophosphohydrolase Deficiency -- 8.12. Gouty Arthritis -- 8.13. Abnormalities of Pyrimidine Metabolism -- References -- 9 Divalent Ion Metabolism -- 9.1. Regulation of Calcium Homeostasis -- 9.2. Phosphate Metabolism -- 9.3. Magnesium Metabolism -- References -- 10 Nutrition, Growth, and Development -- 10.1. Introduction -- 10.2. Malnutrition and the Mechanisms of Cellular Growth -- 10.3. Genetic Obesity -- References -- 11 Metabolic Aspects of Renal Stone Disease -- 11.1. Introduction -- 11.2. Incidence of Renal Stone Disease -- 11.3. Classification of Renal Stone Disease -- 11.4. Renal Stone Disease Secondary to Increased Crystalloid Excretion -- 11.5. Renal Stone Disease Secondary to Physicochemical Changes in Urine Composition -- 11.6. Idiopathic Renal Stone Disease -- 11.7. Treatment of Renal Stone Disease -- References -- 12 Metabolism and Metabolic Actions of Ethanol -- 12.1. Metabolism of Ethanol -- 12.2. Interaction of Ethanol with Androgen Metabolism -- 12.3. Interaction of Ethanol with Amino Acid Metabolism -- 12.4. Effects of Ethanol on the Gastrointestinal Tract -- References