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AuthorMendelson, Wallace B. author
TitleHuman Sleep and Its Disorders [electronic resource] / by Wallace B. Mendelson, J. Christian Gillin, Richard Jed Wyatt
ImprintBoston, MA : Springer US, 1977
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Descript XIV, 260 p. online resource


In this book we trace the development of several major themes in sleep research, from the first formal description of REM sleep in the early 1950s through the present. Chapter 1 provides those less familiar with this area with a perspective on the many possible ways to examine sleep. Chapter 2 describes in detail a major viewpoint of this book: that observations of pharmacological interventions affecting the neurotransยญ mitters may aid in the understanding of sleep regulation. The remainยญ der of the book is devoted to endocrine systems related to sleep (chap. 3) and to the contribution of sleep research to the understanding of various pathological states (chaps. 4-7). The areas of investigation open to those who wish to understand sleep are much broader than the traditional problems of insomnia and narcolepsy. Such disorders as depression, schizophrenia, and alcoholism have long been associated with disordered sleep. Our search for an understanding of the latter phenomena may clarify the nature of these conditions


1 An Introduction to Sleep Studies -- Techniques of Human Sleep Studies -- The Sleep Stages -- The REM-NonREM Cycle -- Sleep Stages and Age -- Effects of Temporal Variables on Sleep -- Physiological Variables Related to the Sleep Stages -- Sleep Deprivation -- Natural Long, Short, and Variable Sleepers -- Regulation of Sleep -- Summary -- 2 A Pharmacologic Approach to Sleep Studies -- Serotonergic System -- Noradrenergic System -- Cholinergic System -- Histaminergic System -- Discussion -- Summary -- 3 Neuroendocrinology and Sleep -- Basic Concepts in Neuroendocrinology -- Growth Hormone -- The Pituitary-Adrenal Axis -- Prolactin -- Follicle-Stimulating Hormone and Luteinizing Hormone -- Thyroid-Stimulating Hormone -- Antidiuretic Hormone -- ADH Secretion during Sleep -- Melatonin -- Summary -- 4 Narcolepsy and Diseases of Excessive Sleep -- Definition -- Natural History -- Epidemiology and Genetics -- Etiology -- Other Disorders of Excessive Daytime Sleep -- Diagnosis -- Pharmacotherapy of Narcolepsy -- Summary -- 5 Clinical Studies of Insomnia -- Normal Sleep -- Incidence of Insomnia -- Kinds of Insomnia -- Tentative List of Causes of Insomnia -- Sleep Induction -- An Approach to Patients Who Complain of Insomnia -- 6 Alcohol, Alcoholism, and the Problem of Dependence -- Animal Studies -- Ethanol in Normal Human Subjects -- Effects of Ethanol on Chronic Alcoholics -- Issues Raised by Observations of the REM Sleep Rebound -- Experimental Therapies -- Summary -- 7 Affective Disorders and Schizophrenia -- Basic Definitions -- Studies of Sleep in Depressed Patients -- Sleep Studies in Schizophrenia -- Summary

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