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TitleMetabolic Effects of Gonadal Hormones and Contraceptive Steroids [electronic resource] / edited by Hilton A. Salhanick, David M. Kipnis, Raymond L. Vande Wiele
ImprintBoston, MA : Springer US, 1995
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The Center for Population Research of the National Institute of Child Health and Human Development began operations in August 1968 and is engaged in research dealing with health-related populaยญ tion problems. We organize and support projects for the developยญ ment of new contraceptives and in the broad field of population research in the social sciences o The Center also supports a variety of projects dealing with the mechanism of action and medical effects of contraceptives now in use, particularly oral contraceptives and intrauterine devices. These studies were initiated several years ago at the specific direction of Congresso We were pleased, therefore, with the opportunity to help organize and support this important and timely conference on the "Metabolic Effects of Gonadal Hormones and Contraceptive Steroids," the subject of which forms an integral part of the Center's research program. April, 1969 Philip Ao Corfman Director Center for Population Research National Institute of Child Health and Human Development v PREFACE Progress in science is often associated with either a "sixth sense" or an inevitable timeliness. Both factors, perhaps, led the members of the Endocrinology Study Section of the National Institutes of Health to propose, in 1966, that an expanded view of the effects of gonadal hormones, in general, and the contraยญ ceptive steroids, in particular. was needed. There had been ample evaluations of the clinical symptomatology, contraceptive efficacy, and effects on the reproductive system, but there was a dearth of information on their multiple systemic'metabolic effects


Liver and Gastrointestinal Tract -- Sex Hormones, the Gastrointestinal Tract and the Liver: Introductory Comments -- Effect of Ethynyl Estradiol on Hepatic Excretory Function of the Rat -- The Effect of Natural and Synthetic Estrogens on the Excretion of BSP by the Liver -- Some Effects of Contraceptive Steroids on Hepatic Function in Normal Women and in Patients with Acquired and Inheritable Defects in Hepatic Excretory Function -- Cholestasis of Pregnancy and During Ethinyl Estradiol Administration in the Human and Rat -- ?-Aminolevulinate Synthetase of the Chick Embryo Liver: The Effect of Natural and Synthetic Sex Steroids on Its Activity -- The Effects of Progesterone Administration on Hepatic Endoplasmic Reticulum: An Electron Microscopic and Biochemical Study -- The Role of Sex Hormones in the Metabolism of Drugs and Other Foreign Compounds by Hepatic Microsomal Enzymes -- Carbohydrate Metabolism -- Effects of Gonadal Hormones and Contraceptive Steroids on Glucose and Insulin Metabolism -- The Effect of Ovarian Steroids on Glucose, Insulin, and Growth Hormone -- Insulin Production in Overt (Maturity-Onset) Diabetes: Absence of Hyperinsulinemia Despite Hyperglycemia Induced by Contraceptive Steroids -- Longitudinal Studies of the Effects of Oral Contraceptive Therapy on Plasma Glucose, Non-Esterfied Fatty Acid, Insulin and Blood Pyruvate Levels During Oral and Intravenous Glucose Tolerance Tests -- Studies of Venous Blood Pyruvate and Lactate Levels During Oral and Intravenous Glucose Tolerance Tests in Women Receiving Oral Contraceptives -- Acquired Subclinical Diabetes Mellitus in Women Receiving Oral Contraceptive Agents -- Lipid Metabolism -- Oral Contraceptives, Lipoproteins, and Lipid Transport -- Fasting Serum Triglyceride and Cholesterol Levels During Oral Contraceptive Therapy -- Studies on the Mechanism of Hypertriglyceridemia Induced by Oral Contraceptives -- Possible Relationship Between Plasma Lipids and Hormonal Steroids -- Gonadal Steroid Effects on Serum Lipids -- Effect of an Oral Contraceptive Steroid Mixture on Some Aspects of Lipid Metabolism in the Rat -- Protein and Amino Acid Metabolism -- Effects of Gonadal and Contraceptive Hormones on Protein and Amino Acid Metabolism -- Metabolic Inhibitors and the Anabolic Actions of Testosterone Propionate -- Androgen Regulation of Mouse Kidney RNA -- Progesterone: Mechanism of Action -- The Effects of Gonadal Hormones and Contraceptive Steroids on Tryptophan Metabolism -- Certain Metabolic Effects of Estrogens -- Respiration -- Effects of Gonadal Hormones and Contraceptive Steroids on Respiration -- Respiratory Effects of Gonadal Hormones -- Hypertension and Electrolytes -- Oral Contraceptives and High Blood Pressure: Changes in Plasma Renin, Renin Substrate and Aldesterone Excretion -- The Effects of Gonadal Hormones on Water and Electrolyte Metabolism in the Human -- Effect of Gonadal Hormones on Adrenocortical Secretion and Its Significance -- Effects of Gonadal Hormones on Plasma Renin Activity and Aldosterone Excretion Rate -- Properties and Origin of Uterine Renin -- Interrelationships of Oral Contraceptives and Hypertension -- Clinical Course and Laboratory Data in Hypertension Associated with Oral Contraceptives -- Calcium and Skeleton -- The Effect of Oral Contraceptives on Calcium Absorption -- Estrogen Effects on the Skeleton -- Effects of Estrogen on Calcium Metabolism in Man -- Effect of Estrogens on the Structure of Bone -- Effects of Estrogens and Progesterones on Collagen Metabolism -- Vascular System -- Thromboembolism and Contraceptive Medication: Incidence and Mechanism -- Effects on the Vascular System and Blood: Epidemiological Studies -- Oral Contraceptives and Excess Mortality from Venous and Pulmonary Thromboembolism in the United States -- Hypercoagulability -- Influence of Hormones on Tissue and Blood Fibrinolytic Activity -- Effect of Contraceptive Hormone Preparations on Plasma Fibrinolytic Activity -- The Role of Blood Platelets in Thrombosis in Relation to the Effects of Contraceptive Steroids on Platelet Function -- Central Nervous System -- The Role of Progestins and Progesterone in Brain Function and Behavior -- The Physiologic Basis for the Temperature Raising Effect of Progesterone -- Assessment of Psychological Concomitants of Oral Contraceptives -- Behavioral Effects of Gonadal Hormones and Contraceptive Steroids in Primates -- Role of the Central Nervous System in the Control of Reproductive Mechanisms by Gonadal Steroids -- Discussion and Appendix -- Discussion -- Drugs Cited in Text

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