Title | Drug Studies in the Elderly [electronic resource] : Methodological Concerns / edited by Neal R. Cutler, Prem K. Narang |
---|---|
Imprint | Boston, MA : Springer US, 1986 |
Connect to | http://dx.doi.org/10.1007/978-1-4684-1253-6 |
Descript | XXVI, 464 p. 38 illus. online resource |
I Research Determinants in Aging -- 1 Epidemiology and Demography of Aging: Some Lessons in Shortsightedness -- 2 Age: A Complex Variable -- 3 Physiological Changes with Aging: Relevance to Drug Study Design -- 4 Immunity and Aging -- 5 Cardiovascular Changes with Aging -- 6 The Effects of Age on Hepatic Drug Metabolism -- 7 Hematological Effects of Aging: Considerations for Clinical Trials -- 8 The Aging Brain -- II Pharmacokinetics and Pharmacodynamics in the Elderly -- 9 The Tricyclic Antidepressants -- 10 Methodological Concerns for Clinical Trials in Geriatrics: Benzodiazepines -- 11 Effect of Age on the Clinical Pharmacokinetics of Antiarrhythmic Drugs -- 12 Beta Blockers in the Elderly -- 13 Antiepileptic Drugs in the Elderly -- 14 Pharmacokinetics and Bioavailability of Corticosteroids in the Treatment of Neurological Diseases of the Elderly -- 15 Pharmacological Treatment of Parkinsonโs Disease -- 16 Cognitive Enhancers in Alzheimerโs Disease -- III General Perspectives -- 17 Dosage Form Considerations in Clinical Trials Involving Elderly Patients -- 18 Clinical Trial DesignโIndustry Perspective -- 19 Methodological Issues: A Regulatory Perspective -- 20 Statistical Analysis of Drug Disposition Data -- 21 Analytical Methods -- 22 Nursing Perspectives on Clinical Trials in Geriatrics