Although serious interest in studying the role of central choยญ linergic processes in psychopathology is just beginning to emerge, experimental literature on the part played by cholinergic mechanisms in brain behavior. reiations is quite extensive. During the past thirty years, cholinergic research has contributed significantly to the characterization and differentiation of adaptive mechanisms inยญ volved in input selection, perception, cortical, autonomic and behavยญ ioral activation, learning, memory, and inhibitory control of behavยญ ioral outputs. To say that dysfunction of one or more of these mechยญ anisms may be at the root of neuropsychiatric illnesses such as schizยญ ophrenia would be stating the obvious. This book examines the part cholinergic processes might play in dysfunctions of the adaptive processes involved in higher brain funcยญ tions and their significance for the pathogenesis, classification, etiology, and treatment of psychopathological conditions. In a series of wide ranging reviews of the available information, the subject is discussed from a variety of perspectives, using data derived from both experimental and clinical research. The purpose is not so much to determine whether cholinergic excess or deficiency is causal in this or that neuropsychiatric syndrome, but rather to try to understand the disease mechanisms in terms of adaptive processes in which cholinergic systems seem to play an important part
CONTENT
1 Historical Overview of Research on Cholinergic Systems and Behavior -- 2 Cholinergic Pathways in the Brain -- 3 Functions of Central Cholinergic Systems in Brain-Behavior -- 4 New Aspects on the Functional Role of Acetylcholine in the Basal Ganglia System. Interactions with other Neurotransmitters -- 5 Central Cholinergic Involvement in Learning and Memory -- 6 Cholinergic Mechanisms in Aggressive Behavior: Role of Muscarinic and Nicotinic Systems -- 7 Cholinergic Mechanisms, Schizophrenia and Neuropsychiatric Adaptive Dysfunctions -- 8 Acetylcholine and Attentional Disorder -- 9 Pharmacology of Central Cholinergic Mechanisms and Schizophrenic Disorders -- 10 Brain Cholinergie Systems and the Pathogenesis of Affective Disorders -- 11 Cholinergie Neuropsychopharmacology and Neuropathology of Dementias -- 12 Cholinergie Mechanisms, Adaptive Brain Processes and Psychopathology: Commentary and a Blueprint for Research
