Author	Marinetti, Guido V. author
Title	Disorders of Lipid Metabolism [electronic resource] / by Guido V. Marinetti
Imprint	Boston, MA : Springer US, 1990
Connect to	http://dx.doi.org/10.1007/978-1-4615-9564-9
Descript	240p. online resource

For the past 30 years I have been teaching lipid biochemistry to'inedical students, graduate students, and undergraduate students. The major topics covered in my courses were fatty acids, prostaglandins, leukotrienes, phospholipids, glycoยญ lipids, triacylglycerols, cholesterol, bile acids, and plasma lipoproteins. Emphaยญ sis was placed on the regulation and disorders of lipid metabolism. The latter included hyperlipidemias, atherosclerosis, and alcohol-induced liver damage. In this volume, I have chosen to focus on the disorders of lipid metabolism at a level appropriate both for medical students and for graduate and undergraduยญ ate students majoring in the biological sciences. The biochemistry, nutrition, genetics, and cell biology aspects of lipids and lipid metabolism will be covered as they relate to lipid disorders. I am not aware of any textbook that integrates the disorders of lipid metabolism in this manner. Chapter 1 includes a brief discussion of the basic structures, properties, and metabolism of lipids. This chapter is not very detailed, since the material covered is available in basic textbooks on biochemistry. The major fpcus of this volume is the various lipid disorders, with emphasis on polyunsaturated fatty acids, the molecular biology and pathogenesis of the hyperlipidemias, dietary and drug therapy for the hyperlipidemias, and alcohol-induced liver damage. The material presented has been obtained from several textbooks on biochemistry and from a variety of recent articles in the scientific literature

1 Disorders of Lipid Digestion and Absorption -- 1.1. Introduction to the Structures and Properties of Lipids -- 1.2. Digestion and Absorption of Lipids -- 1.3. Characteristics of Disorders of Lipid Digestion and Absorption -- References -- 2 Disorders of Fatty Acid Metabolism -- 2.1. General Aspects of Fatty Acid Metabolism -- 2.2. ? Oxidation of Fatty Acids -- 2.3. Disorders of Propionic Acid Metabolism -- 2.4. ? and ? Oxidation of Fatty Acids -- 2.5. Refsumโs Disease -- 2.6. Zellwegerโs Syndrome -- 2.7. Ketogenesis, Ketosis, and Ketoacidosis -- 2.8. Synthesis of Fatty Acids -- 2.9. Essential Fatty Acid Deficiency -- References -- 3 Disorders of Excessive Alcohol Intake: Hypoglycemia, Fatty Liver, and Liver Cirrhosis -- 3.1. Introduction to the Biochemical Effects of Alcohol Intake -- 3.2. Metabolism of Alcohol -- 3.3. Effects of Alcohol Intake on Fatty Acid Metabolism -- 3.4. Alcoholic Hypoglycemia -- 3.5. Alcoholic Hepatitis and Liver Cirrhosis -- 3.6. Effects of Alcohol on the CNS -- 3.7. Effects of Acetaldehyde -- 3.8. Effects of Alcohol on the Heart -- 3.9. Alcohol-Drug Interactions -- 3.10. Alcohol Withdrawal Symptoms -- 3.11. Alcohol Intake and Heart Disease -- References -- 4 Disorders of Cholesterol Metabolism: Cholesterol Storage Diseases -- 4.1. Overall Cholesterol Balance in Humans -- 4.2. Synthesis of Cholesterol -- 4.3. Conversion of Cholesterol to Bile Acids -- 4.4. Abnormalities of Cholesterol Metabolism -- 4.5. Cholelithiasis (Gallstones) -- References -- 5 Disorders of Lipoprotein Metabolism: Dyslipoproteinemias -- 5.1. Plasma Lipoproteins and Apoproteins: General Aspects -- 5.2. Structure and Function of Apoproteins -- 5.3. Metabolism of Lipoproteins -- 5.4. LDL, LDL Receptor, and HMGR -- 5.5. Pathogenesis of Hyperlipoproteinemias -- 5.6. Factors Leading to Hyperlipidemias -- 5.7. Mechanisms of Hyperlipidemias -- 5.8. Lipoprotein Metabolism in Diabetes -- 5.9. Hypolipoproteinemias -- References -- 6 Cholesterol, Lipoproteins, and Atherosclerosis -- 6.1. Atherosclerosis -- 6.2. Survey Studies: Cholesterol and CHD -- 6.3. Alcohol Intake and CHD -- 6.4. Drug Therapy for Hyperlipidemias -- 6.5. Postulated Mechanisms of Atherosclerosis -- References -- 7 Dietary Management of Elevated Blood Lipids -- 7.1. Dietary Lipids, Hyperlipidemia, and Heart Disease -- 7.2. Biochemical Effects of Polyunsaturated Fatty Acids -- 7.3. Platelet and Blood Vessel Prostaglandins Derived from Dietary Polyunsaturated Fatty Acids -- 7.4. Effects of Polyunsaturated Fatty Acids on Platelet Function -- 7.5. Platelet Lipid Composition -- 7.6. Platelet and Vascular Function -- 7.7. Mechanisms of Fatty Acid Effects -- 7.8. Possible Risks and Side Effects from Increased Amounts of Dietary Polyunsaturated Fatty Acids -- References -- 8 Drug Therapy for Hyperlipidemias: Lipid-Lowering Drugs and Antithrombic and Fibrinolytic Drugs -- 8.1. Lipid-Lowering Drugs -- 8.2. Combined Drug Therapy -- 8.3. Antithrombic Drugs -- 8.4. Fibrinolytic Drugs -- 8.5. Mechanisms of Action of Antithrombic Drugs -- 8.6. Arachidonic Acid Release Inhibitors -- 8.7. Drugs That Inhibit cAMP Formation in Platelets -- 8.8. Membrane-Active Drugs -- 8.9. Anticoagulants and Other Drugs -- 8.10. Antithrombic Drugs for Treatment of CHD -- References -- 9 Lung Surfactant Deficiency: Respiratory Distress Syndrome of the Newborn -- 9.1. Early History -- 9.2. Properties of DPPC -- 9.3. Lung Surfactant -- 9.4. Synthesis of Lung Surfactant Phospholipids -- 9.5. Hormonal Regulation of the Synthesis of Lung Surfactant -- 9.6. Therapy for RDS -- References -- 10 Sphingolipidoses: Gangliosidoses, Tay-Sachs Disease, and Sandhoffโs Disease -- 10.1. Early History -- 10.2. Genetic Defects -- 10.3. Sphingolipids -- 10.4. Overview of the Sphingolipidoses -- 10.5. Therapeutic Approaches for the Sphingolipidoses -- References

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