Leukoderma is a generic term for any pigmentary dilution, be it congenital or acquired, circumscribed or generalized, devoid of or partially lacking in pigยญ mentation. In the approach to the diagnosis of leukoderma, we have generally first considered the age of onset, whether leukoderma was congenital or acยญ quired, the extent and pattern of involvement, and the degree of pigmentary dilution. The organization of this monograph reflects this approach. For exยญ ample, we have separated the section devoted to various disease entities into diffuse and circumscribed leukoderma and the latter into various etiologies such as genetic, metabolic, infectious, and endocrinologic. One of several justifications for this monograph is to present an approach to the diagnosis of leukoderma, as detailed in Part II. In formulating a guide for the physician, we have found some limitations to our previous approach; we therefore offer the following new classification based upon a cliniยญ cal-pathologic correlation. This could provide the means to describe both the clinical and pathologic findings in one term
CONTENT
I. Skin Color and the Melanin Pigmentary System -- II. Approach to the Problem of Leukoderma -- III. Hypomelanotic Disorders -- 1. Genetic and Congenital Disorders -- 2. Hypomelanoses Associated with Nutritional and Metabolic Disorders -- 3. Hypomelanosis Associated with Endocrine Disorders -- 4. Hypomelanosis Secondary to Irradiation and Physical Trauma -- 5. Chemical Hypomelanosis -- 6. Hypomelanosis Associated with Inflammation -- 7. Infectious and Parasitic Hypomelanosis -- 8. Leukoderma Acquisitum Centrifugum: Halo Nevus and Other Hypomelanoses Associated with Neoplasms -- 9. Miscellaneous Hypomelanoses -- IV. Leukodermas without Hypomelanosis
