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TitleArterial Lesions and Arteriosclerosis [electronic resource] / edited by H. Jellinek
ImprintBoston, MA : Springer US, 1974
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Descript 338 p. online resource


This monograph summarizes the results of a fifteen-year vascular pathology research project sponsored by the Hungarian Academy of Sciences. The workers who have participated in this project are indebted to the Academy for financing extensive investigations and visits to institutes abroad, the aims of which were to solve certain problems by international cooperation. The results presented by the collective effort of research teams, each studying here have been achieved a particular problem, but working together to the same end. Mutual discussion of findings and a regular exchange of information between the research groups have contributed to the progress of the investigations. Regular pUblication of details and mutual criticism ensured that the findings were uniformly interpreted. It is hoped that the fundamental aim of our long-term project, i. e. the selection of the right approach to the complex problem of vascular pathology, has been achieved. The new approach results from the recognition that since arteriosclerosis finally leads to various kinds of vascular injury, attention should be focussed on the events preceding the development of the lesions rather than on the lesions themselves. This claim has been confirmed by various model experiments in which vascular injury inflicted under different conditions uniformly led to morphologiยญ cally verified arteriosclerotic change. The recent increase in the incidence of civiยญ lization diseases of the vascular system has resulted in a world-wide expansion of arteriosclerosis research


Preface -- 1 The Fine Structure of the Mammalian Arterial Wall -- The structural effect of vascular preservation -- Components of the normal arterial wall -- 2 Aortic Response to Various Effects -- Development and structure of regenerative IP -- 3 Development and Ultra Structure of Arteriosclerotic Lesions -- Ultrastructure of arteriosclerotic lesions -- 4 Studies of Large Muscular Vessels -- 5 Morphological Changes of Small Muscular-Type Vessels and Arterioles under the Influence of Various Injuries -- Lesions of muscular-type small vessels in acute experimental hypertension -- Acute hypertensive lesions of small vessels as a model of vascular damage -- Acute hypertensive lesion of the intima -- 6 Experimental Observations -- Investigations by light microscopy -- Mechanism of development of the subendothelial fibrinoid -- Histochemistry of acute vascular lesions -- Acid muscopolysaccharide (AMP) synthesis in experimental hypertension of muscular-type small arteries -- Morphological changes of small vessels after painting with acid -- Noradrenalin-induced lesions of muscular-type small vessels -- Small vessel changes on hypersensitization -- 7 Chronic Lesions of Small Vessels (Vascular Wall Transformation Following acute Lesions of Small Vessels) -- Chronic small vessel changes after hypertension -- Chronic proliferative reactions of vessels damaged by a single trauma or by an acute hypertensive crisis -- Small vessel hyalinization after an acute hypertensive crisis or other singular damage -- Proliferative vascular lesions in chronic benign hypertension -- Hyaline vascular changes in chronic benign hypertension -- Hypoxic vascular changes -- Chronic transformation of vascular lesions induced by painting with acid, noradrenalin administration or sensitization with horse serum -- 8 Influence of Drug Therapy on Small Vessel Changes in Experimental Hypertension, Problems of Healing and Reversibility -- 9 Conclusions from available Experimental data on the Role of Vascular Structure in the Morphology of Vascular Lesions -- 10 Problems of Transport Across the Vessel Wall -- Methods of tracing the transmural passage of material. Colloidal tracers -- Factors responsible for intramural transport -- Intramural diffusion of various plasma substances -- Pressure and flow factors -- Effect of hypertension on transport across the vessel wall -- Arteriosclerosis and mural transport -- 11 Studies on Human Vascular Diseases with Regard to Observations in Model Experiments -- Evaluation of acute small vessel lesions -- Chronic lesions of small vessels -- Correlation of human large vessel lesions with similar changes in experimental animals -- Description of Surgical Methods and Fixing and Staining Techniques Frequently Referred to in this Book -- Publications by the Editor and his Team -- General Bibliography -- Plates

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