Title | Gene Transfer in the Cardiovascular System [electronic resource] : Experimental Approaches and Therapeutic Implications / edited by Keith L. March |
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Imprint | Boston, MA : Springer US : Imprint: Springer, 1997 |
Connect to | http://dx.doi.org/10.1007/978-1-4615-6277-1 |
Descript | XX, 516 p. online resource |
Vectors and Gene Transfer Systems: Molecular Aspects of Delivery -- 1. Development of Viral Vectors for Human Gene Therapy: Retrovirus and Adenovirus (Part I) -- 2. Adenoviruses (Part II): Improvement of Adenoviral Vectors for Human Gene Therapy: E1 and E4 Deleted Recombinant Adenoviruses -- 3. Adeno-associated Virus and Other New DNA Virus Vectors -- 4. Plasmid and Other Non-Viral Vectors -- 5. The HVJ/Liposome Molecular Delivery System for In Vivo Genetic Engineering -- 6. Endogenous Expression Modification: Antisense Approaches -- Methods for Localizing Gene Transfer: Mechanical Aspects of Delivery -- 7. Catheter-Based Local Drug and Gene Delivery -- 8. Fluid Dynamics of Catheter Delivery: Effects on Delivery Efficiency and Localization -- 9. Targeted and Sustained-Release Delivery Concepts in Gene Therapy -- Gene Delivery for Local Vascular Expression -- 10. Viral Vector-Based Vascular Gene Delivery: Basic Studies and Therapeutic Applications -- 11. Cell-Based Vascular Gene Delivery: Endothelial Cells as Carriers -- 12. Cell-Based Gene Delivery: Smooth Muscle Cells as Carriers -- 13. Vascular Cell Proliferation Dynamics: Implications for Gene Transfer and Restenosis -- 14. Angiogenesis and Collateral formation -- Gene Delivery for Local Cardiac Expression -- 15. Cell-Based Myocardial Protein Delivery -- 16. Skeletal Myoblast Therapy in Cardiovascular Disease -- 17. Adenovirus and the Myocardium -- Gene Delivery for Systemic Expression -- 18. Gene Delivery for Systemic Expression: Plasmid, Retroviral, and Adenoviral Approaches -- 19. Adenoviral Gene Delivery Approaches for Systemic Expression -- 20. Experimental Approaches Using Kallikrein Gene Therapy for Hypertension -- Biophysical Considerations in Vector Delivery -- 21.Pharmacokinetics of Local Vector Delivery To Vascular Tissues: Implications for Efficiency and Localization -- Color Plates