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TitleDegenerative Retinal Diseases [electronic resource] / edited by Matthew M. LaVail, Joe G. Hollyfield, Robert E. Anderson
ImprintBoston, MA : Springer US : Imprint: Springer, 1997
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Descript XIII, 426 p. online resource


Since 1984, we have organized Satellite Symposia on Retinal Degenerations that are held in conjunction with the biennial International Congress of Eye Research. The timing and location of our Retinal Degeneration Symposia have all owed scientists and clinicians from around the world to convene and present their exciting new findings. The symposia have been arranged to allow ample time for discussions and one-on-one interactions in a relaxed atmosยญ phere, where international friendships and collaborations could be established. The II International Symposium (also known as the Sendai Symposium on Retinal Degeneration) was held in 1986 in Sendai, Japan, on the occasion of the retirement of Katยญ suyoshi Mizuno as Professor and Chairman of Ophthalmology at Tohoku Medical SchooL On October 5-9, 1996, we returned to Sendai, where the VII International Symposium was held at the Miyagi Zao resort hotel in the beautiful Mt. Zao region of northern Japan. This meeting was held on the occasion of the tenth anniversary of Makoto Tarnai as Proยญ fessor and Chairman of Ophthalmology at Tohoku Medical School. One afternoon of the meeting contained a special symposium in honor of Professor Tarnai, who has signifiยญ cantly elevated the level and intensity of research on retinal degenerations at his university and in Japan during this past decade


I. Cytopathologic, Physiologic, Diagnostic, and Clinical Aspects of Retinal Degeneration -- 1. Histochemical Comparison of Ocular โ{128}{156}Drusenโ{128}{157} in Monkey and Human -- 2. TIMP-3 Accumulation in Bruchโ{128}{153}s Membrane and Drusen in Eyes from Normal and Age-Related Macular Degeneration Donors -- 3. Photoreceptor Rosettes in Age-Related Macular Degeneration Donor Tissues -- 4. Central Retinal Sensitivity Repeated Measurements as Long Term Follow-up in Retinitis Pigmentosa -- 5. Complete and Incomplete Type Congenital Stationary Night Blindness (CSNB) as a Model of โ{128}{156}OFF-Retinaโ{128}{157} and โ{128}{156}ON-Retinaโ{128}{157} -- 6. A Family with X-Linked Cone Dystrophy Showing a Tapetal-like Reflex -- 7. Autoimmune Retinopathy: Cystoid Macular Edema in Retinitis Pigmentosa Patients -- 8. Norrie Disease in Japan -- II. Animal Models of Retinal Degeneration -- 9. Development of a Model for Macular Degeneration -- 10. Subretinal Iodoacetate: A Model of Retinal Degeneration in Cats -- 11. Hereditary Retinal Dystrophy of Swedish Briard Dogs: Exclusion of Six Candidate Genes by Molecular Genetic Analysis -- 12. The VPP Mouse: A Transgenic Model of Autosomal Dominant Retinitis Pigmentosa -- 13. Altered Regulation of Ion Channels in Cultured Retinal Pigment Epithelial Cells from RCS Rats -- 14. Structures of the Oligosaccharides of Rhodopsin from Normal and RCS Rats -- 15. Indocyanine Green Videoangiography in the Royal College of Surgeons Rat -- 16. Defective Choroidal Angiogenesis Precedes Retinal Pigment Epithelial Phagocytic Defect in Neonatal RCS Rats -- 17. Comparative Biology of Retinoid Deprivation and Replacement in Flies and Rodents -- 18. Rhodopsin-Dependent Models of Drosophila Photoreceptor Degeneration -- 19. Recessive Degeneration of Photoreceptor Cells Caused by Point Mutations in the Cytoplasmic Domains of Drosophila Rhodopsin -- III. Mechanisms of Retinal Degeneration and Cell Death -- 20. Nitric Oxide-Induced Increases in Retinal cGMP: A Role in Photoreceptor Degenerations -- 21. Glycohistochemical Study of Light-Induced Retinal Degeneration: Removal System of Apoptotic Cells -- 22. Light-Induced Retinal Degeneration Is Prevented in Mice Lacking c-fos -- 23. Ischemic Neuronal Death in the Fish Retina: In Respect of Oxygen Radicals and Glutathione -- IV. Candidate Genes, Cloning, Mapping, and Other Molecular Genetics of Retinal Degeneration -- 24. Isolation of Candidate Genes for Retinal Degenerations -- 25. Studies on the Cone Cyclic GMP-Phosphodiesterase ?โ{128}{153} Subunit Gene -- 26. Mutations in PDE6A, the Gene Encoding the a-Subunit of Rod Photoreceptor cGMP-Specific Phosphodiesterase, Are Rare in Autosomal Recessive Retinitis Pigmentosa -- 27. Molecular Analysis of the Human PEDF Gene, a Candidate Gene for Retinal Degeneration: Localization to 17pl3.3 -- 28. Screening of Candidate Genes on Japanese Retinal Dystrophies -- 29. Strategies for the Genetic Analysis of Autosomal Recessive Retinitis Pigmentosa in Spanish Families -- 30. Progress in Positional Cloning of RP10 (7q31.3), RP1 (8q11โ{128}{147}q21), and VMD1 (8q24) -- 31. Growth Factors in the Retina: Pigment Epithelium-Derived Factor (PEDF) Now Fine Mapped to 17pl3.3 and Tightly Linked to the RP13 Locus -- 32. Genetic and Physical Localisation of the Gene Causing Cone-Rod Dystrophy (CORD2) -- 33. Usher Syndrome Type 1C: Localization to Chromosome 11p14 and Construction of a YAC Contig -- 34. Oguchi Disease, Retinitis Pigmentosa, and the Phototransduction Pathway -- 35. A Patient with Progressive Retinal Degeneration Associated with Homozygous 1147delA Mutation in the Arrestin Gene -- V. Transplantation, Gene Therapy, and Cell Rescue -- 36. bFGF Transfected Iris Pigment Epithelial Cells Rescue Photoreceptor Cell Degeneration in RCS Rats -- 37. Transplantation of Neonatal Neural Retina in Photoreceptor Degeneration of Cats -- 38. Mechanical Aspects of Retinal Pigment Epithelial Transplantation -- 39. Midkine from Various Sources in Constant Light-Induced Photoreceptor Degeneration of the Rat -- 40. The Influence of Oxygen on the Survival and Death of Photoreceptors: Evidence from Rat and Mouse -- 41. Histological Method to Assess Photoreceptor Light Damage and Protection by Survival Factors -- VI. Structural, Physiologic, and Aging Correlates of Retinal Degeneration -- 42. Further Studies on the Phagocytosis of Photoreceptor Outer Segments by Rat Retinal Pigment Epithelial Cells -- 43. Purification and Characterization of Matrix Metalloproteinase-3 (Stromelysin-1) from Bovine Interphotoreceptor Matrix -- 44. Senile Retinal Deficiencies in Astrocytes and Blood Vessels -- Corresponding Authors by Chapter Number

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